Immunoallergic Granulomatous Interstitial Nephritis following Treatment with Omeprazole
| Autor: | Jean-Jacques Montseny, Alain Meyrier |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Male
Pathology medicine.medical_specialty Interstitial nephritis Ocular myasthenia Kidney Autoimmune Diseases Ocular Motility Disorders Fibrosis Myasthenia Gravis Humans Medicine Omeprazole Aged medicine.diagnostic_test business.industry Anti-Ulcer Agents medicine.disease medicine.anatomical_structure Nephrology Nephritis Interstitial Renal biopsy business Nephritis medicine.drug Kidney disease |
| Zdroj: | American Journal of Nephrology. 18:243-246 |
| ISSN: | 1421-9670 0250-8095 |
| DOI: | 10.1159/000013345 |
| Popis: | A 69-year-old male who had a long history of ocular myasthenia was treated with omeprazole for 3 months. Progressive renal insufficiency was discovered fortuitously. There were no clinical or laboratory manifestations of immunoallergy. Renal biopsy revealed severe granulomatous interstitial nephritis, tubular injury and fibrosis. Histology of a liver nodule disclosed hepatic granulomatous involvement. Withdrawal of omeprazole and a short course of corticosteroids were followed by improvement but not normalization of renal function. This is the eighth report of omeprazole-induced interstitial nephritis. In the present case as in 2 others in the literature, the patients had been followed up for an autoimmune disease previously, which suggests that in patients with such a background, patients should be examined regularly for renal functional impairment during treatment with omeprazole. |
| Databáze: | OpenAIRE |
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