MRI and Neuropsychological Correlates in African Americans With Hypertension and Left Ventricular Hypertrophy

Autor: Phillip D. Levy, E. Mark Haacke, Jason E Kisser, Rachelle Dawood, Brigid Waldron-Perrine, Aaron Brody, Scott R. Millis
Rok vydání: 2018
Předmět:
Adult
Male
medicine.medical_specialty
Michigan
Trail Making Test
Blood Pressure
030204 cardiovascular system & hematology
Motor Activity
Neuropsychological Tests
Left ventricular hypertrophy
Brief Communication
Ventricular Function
Left
03 medical and health sciences
Executive Function
0302 clinical medicine
Leukoencephalopathies
Memory
Predictive Value of Tests
Risk Factors
Internal medicine
Internal Medicine
medicine
Humans
Neuropsychological assessment
Aged
Psychomotor learning
medicine.diagnostic_test
Ventricular Remodeling
business.industry
Neuropsychology
Controlled Oral Word Association Test
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Hyperintensity
Black or African American
Finger tapping
Hypertension
Cardiology
Female
Hypertrophy
Left Ventricular
business
030217 neurology & neurosurgery
Zdroj: American journal of hypertension. 31(8)
ISSN: 1941-7225
Popis: BACKGROUND African Americans (AAs) are at high risk for hypertension (HTN) and poor blood pressure (BP) control. Persistently elevated BP contributes to cardiovascular morbidity. White matter hyperintensities (WMHs) are a definable magnetic resonance imaging (MRI) marker of cerebrovascular injury linked to impairments in higher level thinking (i.e., executive functions), memory formation, and speed of perceptual-motor processing. METHODS This subinvestigation evaluated neuropsychological functioning in association with WMH on brain MRIs in 23 otherwise-healthy hypertensive AAs participating in an NIH-funded study of the effects of vitamin D on BP and cardiac remodeling in AA patients 30–74 years of age with HTN and left ventricular hypertrophy. Neuropsychological assessment included psychomotor processing speed [(Symbol Digit Modality Test (SDMT) and Trail Making Test], executive functioning (Controlled Oral Word Association Test and Trail Making Test Part B), memory (Rey Auditory Verbal Learning Test), and fine motor functioning (Finger Tapping). RESULTS Significant correlations (P < 0.05) were found between volume of periventricular lesions and trails A (r = 0.51) and dominant hand finger tapping speed (r = −0.69) and between subcortical lesion volume and trails A (r = 0.60), both dominant (r = −0.62) and nondominant hand finger tapping speed (r = −0.76) and oral SDMT (r = −0.60); higher lesion volumes correlated to worse neuropsychological performance. CONCLUSIONS Psychomotor tests including the Trail Making Test and finger tapping speed are sensitive indicators of subclinical deficits in mental processing speed and could serve as early markers of deep subcortical cerebrovascular injury in otherwise-healthy individuals with uncontrolled chronic HTN.
Databáze: OpenAIRE
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