Estimating Recombination Fraction Separately for Males and Females: A Counterintuitive Result

Autor:	Hodge Se, Duryea Mf, Pamela Flodman, M. A. Spence
Rok vydání:	1998
Předmět:	Male Recombination Genetic Linkage (software) Genetics Models Genetic Counterintuitive Biology Rats Inbred WKY Rats Genetic linkage Rats Inbred SHR Animals Female Statistical analysis Genetics (clinical) Recombination Fraction Lod scores
Zdroj:	Human Heredity. 48:42-48
ISSN:	1423-0062 0001-5652
DOI:	10.1159/000022780
Popis:	In the course of performing a linkage analysis on rats bred from inbred doubly heterozygous parents, we observed the following counterintuitive finding: the lod scores more strongly supported the hypothesis that all the recombinations occurred in one sex (without specifying which sex), rather than that some recombinations occurred in each sex. In this brief paper we explain how this apparent anomaly can arise. We point out that very different values of the recombination fraction vector θ = (θ♀, θ♂) can give rise to likelihoods that do not differ by much. We suggest that caution be exercised when investigators interpret results of linkage analyses in which estimates of θ♀ and θ♂ differ widely.
Databáze:	OpenAIRE
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