Relationship Between White Matter Abnormalities and Neuropsychological Measures in Children With ADHD
| Autor: | Hichem Slama, Ariadna Albajara Sáenz, Isabelle Massat, Philippe Peigneux, Simon Baijot, Alison Mary, Thierry Metens, Thomas Villemonteix, Martin Kavec, Danielle Balériaux |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Audiology behavioral disciplines and activities White matter 03 medical and health sciences 0302 clinical medicine mental disorders Fractional anisotropy Developmental and Educational Psychology medicine Humans Cingulum (brain) 0501 psychology and cognitive sciences Child Working memory 05 social sciences Superior longitudinal fasciculus Neuropsychology Brain White Matter Inhibition Psychological Clinical Psychology Diffusion Tensor Imaging medicine.anatomical_structure Attention Deficit Disorder with Hyperactivity Nerve Net Abnormality Psychology 030217 neurology & neurosurgery 050104 developmental & child psychology Diffusion MRI |
| Zdroj: | Journal of Attention Disorders. 24:1020-1031 |
| ISSN: | 1557-1246 1087-0547 |
| DOI: | 10.1177/1087054718787878 |
| Popis: | Objective: Using Diffusion Tensor Imaging (DTI), to investigate microstructural white matter differences between ADHD and typically developing children (TDC), and their association with inhibition and working memory performance usually impaired in ADHD. Method: Fractional anisotropy (FA) and mean diffusivity (MD) were estimated in 36 noncomorbid children with a Diagnostic and Statistical Manual of Mental Disorders (4th ed., text rev.; DSM-IV-TR) diagnosis of combined type ADHD and 20 TDC. Correlations between FA/MD and Stop Signal Task and N-Back performance parameters were computed. Results: Working memory performance was significantly associated with MD in the superior longitudinal fasciculus (SLF) and the cingulum in the ADHD group. No between-group differences in FA/MD reached significance, after controlling for between-group head motion differences. Conclusion: The association between white matter integrity in the cingulum and the SLF and working memory performance confirms previous studies. Our results also show that when critical conditions are controlled (age, comorbidity, head motion), no ADHD-related structural abnormality (FA/MD) are observed, in line with prior suggestions. |
| Databáze: | OpenAIRE |
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