Surface arming magnetic nanoparticles with amine N-halamines as recyclable antibacterial agents: Construction and evaluation
| Autor: | Tianyi Gao, Chokto Harnoode, Ying Liu, Linghan Xiao, Alideertu Dong, Yanling Zhang, Quanfu Yao, Yangyang Gao |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Staphylococcus aureus
Surface Properties Nanoparticle chemistry.chemical_element Microbial Sensitivity Tests 02 engineering and technology 010402 general chemistry 01 natural sciences Nanomaterials chemistry.chemical_compound Colloid and Surface Chemistry Spectroscopy Fourier Transform Infrared Escherichia coli Chlorine Organic chemistry Agar diffusion test Amines Physical and Theoretical Chemistry Magnetite Nanoparticles biology Photoelectron Spectroscopy Surfaces and Interfaces General Medicine equipment and supplies 021001 nanoscience & nanotechnology biology.organism_classification Combinatorial chemistry Anti-Bacterial Agents 0104 chemical sciences chemistry Magnetic nanoparticles Amine gas treating 0210 nano-technology human activities Bacteria Iron oxide nanoparticles Biotechnology |
| Zdroj: | Colloids and Surfaces B: Biointerfaces. 144:319-326 |
| ISSN: | 0927-7765 |
| DOI: | 10.1016/j.colsurfb.2016.04.024 |
| Popis: | Magnetic recyclable antibacterial nanomaterials, i.e., magnetic amine N-halamine nanoparticles (Fe3O4@SiO2/CTMP NPs), were constructed by arming magnetic silica nanoparticles (Fe3O4@SiO2 NPs) with amine N-halamine (CTMP). Magnetic iron oxide nanoparticles were encapsulated into silica layers followed by anchoring antibacterial amine N-halamines to give magnetic/antibacterial bi-functional agents with core-shell structure. Since the presence of Fe3O4 NPs in core, the products offer super-paramagnetic behavior, which made them separable magnetically after the antibacterial behavior. Their sterilizing effect on bacterial strain was evaluated using Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as model bacteria via the plate counting technique, zone of inhibition study, and time kill assay. Antibacterial mechanism study illustrated that the products integrate both the contact mechanism and the release mechanism for attacking bacteria. The significant effect of oxidative chlorine content and concentration of the products on antibiotic action were confirmed. Thanks to the magnetic property, the potential recyclability of the products was achieved. Most significantly, the products retain effective antibacterial action even after five cycles. These findings revealed that the products Fe3O4@SiO2/CTMP NPs have promising applications in the antibacterial fields. |
| Databáze: | OpenAIRE |
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