Targeting the Hippo/YAP/TAZ signalling pathway: Novel opportunities for therapeutic interventions into skin cancers

Autor:	Alexander Howard, Jodie Bojko, Benjamin Flynn, Sophie Bowen, Ute Jungwirth, Gernot Walko
Rok vydání:	2022
Předmět:	Cell Transformation Neoplastic Skin Neoplasms Transcriptional Coactivator with PDZ-Binding Motif Proteins Trans-Activators Humans YAP-Signaling Proteins Dermatology Molecular Biology Biochemistry Adaptor Proteins Signal Transducing Transcription Factors
Zdroj:	Experimental dermatology. 31(10)
ISSN:	1600-0625
Popis:	Skin cancers are by far the most frequently diagnosed human cancers. The closely related transcriptional co-regulator proteins YAP and TAZ (WWTR1) have emerged as important drivers of tumour initiation, progression and metastasis in melanoma and non-melanoma skin cancers. YAP/TAZ serve as an essential signalling hub by integrating signals from multiple upstream pathways. In this review, we summarize the roles of YAP/TAZ in skin physiology and tumorigenesis and discuss recent efforts of therapeutic interventions that target YAP/TAZ in in both preclinical and clinical settings, as well as their prospects for use as skin cancer treatments.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e12186dd763f9bc802b4de607fa38a33 https://pubmed.ncbi.nlm.nih.gov/35913427 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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