IL-1α, IL-6 and IL-8 serum values in patients with chronic suppurative otitis media

Autor: Bogdan Mihail Diaconescu, Luminita Radulescu, Bogdan Mihail Cobzeanu, Roxana Serban, Minerva Codruta Badescu, Mihail Dan Cobzeanu, Magda Badescu, Cristiana Filip
Rok vydání: 2021
Předmět:
Zdroj: Experimental and Therapeutic Medicine
ISSN: 1792-1015
Popis: Inflammatory mediators play an important role in the pathogenesis of otitis media by initiating and maintaining an inflammatory response to infection. The presence of inflammatory mediators may be one of the reasons, in some patients, for acute otitis media transforming into chronic otitis media. The present study included 60 patients admitted to the Clinical Rehabilitation Hospital, Iasi, Romania, for surgery. The control group comprised 30 healthy individuals. Serum levels of interleukin 1α (IL-1α), interleukin 6 (IL-6) and interleukin 8 (IL-8) were measured prior to surgery and were compared among patients with chronic suppurative otitis media (CSOM), cholesteatoma and cholesteatoma recidivism and the control group. High serum levels of interleukins were recorded in all the groups compared to the healthy control group. IL-6 and IL-8 had the highest value in patients with CSOM and IL-1α had the highest value in patients with cholesteatoma recidivism. Thus, we can consider that inflammatory mediators play a central role in the pathogenesis of CSOM and cholesteatoma by maintaining a systemic and local inflammatory response.
Databáze: OpenAIRE
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