Serum irisin levels are lower in patients with breast cancer: association with disease diagnosis and tumor characteristics
| Autor: | Maira A. Matiatou, George C. Zografos, Xeni Provatopoulou, Antonia Gounaris, Georgia Georgiou, Eleni Kalogera, Vasileios Kalles, Alexandros Sagkriotis, Ioannis Papapanagiotou |
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| Rok vydání: | 2015 |
| Předmět: |
Oncology
Adult Leptin Cancer Research medicine.medical_specialty Irisin Breast Neoplasms Diagnostic indicator Sensitivity and Specificity Body Mass Index Breast cancer Internal medicine Myokine Genetics medicine Biomarkers Tumor Humans Serum levels Aged Adiponectin business.industry Carcinoma Ductal Breast Case-control study Cancer Middle Aged medicine.disease Fibronectins Endocrinology Logistic Models Case-Control Studies Resistin Female business Body mass index Research Article |
| Zdroj: | BMC Cancer |
| ISSN: | 1471-2407 |
| Popis: | Background Irisin is a recently discovered myokine, involved in the browning of white adipose tissue. To date, its function has been mainly associated with energy homeostasis and metabolism, and it has been proposed as a promising therapeutic target for obesity and metabolic diseases. This is the first study investigating the role of irisin in human breast cancer. Methods Participants included one hundred and one (101) female patients with invasive ductal breast cancer and fifty one (51) healthy women. Serum levels of irisin, leptin, adiponectin and resistin were quantified in duplicates by ELISA. Serum levels of CEA, CA 15–3 and Her-2/neu were measured on an immunology analyzer. The association between irisin and breast cancer was examined by logistic regression analysis. The feasibility of serum irisin in discriminating breast cancer patients was assessed by ROC curve analysis. Potential correlations with demographic, anthropometric and clinical parameters, with markers of adiposity and with breast tumor characteristics were also investigated. Results Serum levels of irisin were significantly lower in breast cancer patients compared to controls (2.47 ± 0.57 and 3.24 ± 0.66 μg/ml, respectively, p |
| Databáze: | OpenAIRE |
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