Hepatotoxicity in Guinea Pigs Following Acute Inhalation Exposure to 1,1-Dichloro-2,2,2-Trifluoroethane
| Autor: | Darol E. Dodd, Marilyn E. George, Allen Vinegar, Gary B. Marit |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Pathology medicine.medical_specialty Necrosis 040301 veterinary sciences Guinea Pigs Physiology Biology Toxicology 030226 pharmacology & pharmacy Pathology and Forensic Medicine 0403 veterinary science Guinea pig 03 medical and health sciences 0302 clinical medicine Administration Inhalation medicine Animals Molecular Biology Inhalation exposure Hepatitis Kidney Inhalation 04 agricultural and veterinary sciences Cell Biology medicine.disease medicine.anatomical_structure Chlorofluorocarbons Ethane Liver Toxicity Halothane medicine.symptom Chlorofluorocarbons medicine.drug |
| Zdroj: | Toxicologic Pathology. 22:404-414 |
| ISSN: | 1533-1601 0192-6233 |
| Popis: | Groups of 10 male Hartley guinea pigs were exposed to 3.0, 2.0, 1.0, or 0.1% (v/v) 1,1-Dichloro-2,2,2-trifluoroethane (HCFC-123) or 1.0% (v/v) halothane by inhalation for 4 hr. A sixth group of 10 guinea pigs received only air. All animals were sacrificed 48 hr postexposure. Gross and histopathologic examination of the liver, heart, and kidney and routine hematology and clinical chemistry analyses [including isocitrate dehydrogenase (ICDH)] were done on all guinea pigs. Lesions related to HCFC-123 and halothane exposure were limited to the liver and included centrolobular vacuolar (fatty) change, multifocal random degeneration and necrosis, and centrolobular degeneration and necrosis. These lesions were observed in 90-100% of the exposed animals and were absent in the air-only controls. There was significant individual animal variation in susceptibility to both HCFC-123 and halothane, resulting in a spectrum of histologic lesions and clinical chemistry values within each exposure group. Alanine aminotransferase, aspartate aminotransferase, and ICDH were the most significant predictors of hepatocellular damage. Similarities in the response between halothane and HCFC-123 in this guinea pig model suggests that humans susceptible to halothane-induced hepatitis may be susceptible to HCFC-123 by a common mechanism of toxicity. |
| Databáze: | OpenAIRE |
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