Targeting proteasomes for cardioprotection
| Autor: | Xichun Yu, Eugene Patterson, David C. Kem |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
Cardioprotection Proteasome Endopeptidase Complex Programmed cell death G-Protein-Coupled Receptor Kinase 2 Heart Diseases Ubiquitin Cell growth Inflammation Disease Biology Muscle hypertrophy Cell biology Pathogenesis Drug Delivery Systems Proteasome Drug Discovery Immunology medicine Animals Humans medicine.symptom Proteasome Inhibitors |
| Zdroj: | Current Opinion in Pharmacology. 9:167-172 |
| ISSN: | 1471-4892 |
| DOI: | 10.1016/j.coph.2008.11.005 |
| Popis: | The ubiquitin-proteasome system (UPS) plays a central role in intracellular protein degradation and regulates many cellular processes, including cell proliferation, inflammation, adaptation to stress, cell death, and the removal of damaged or misfolded proteins. Numerous studies have demonstrated that altered UPS function is involved in the pathogenesis of a wide range of cardiac diseases including hypertrophy and failure, myocardial ischemia, atherosclerosis, and diabetic cardiovascular disease. Impairment of proteasome function is a common feature of cardiac disease; however several studies have also demonstrated increased proteasome activity in models similar but not identical with those having decreased function. Recent studies have shown that use of proteasome inhibitors before or following production of the model of cardiac disease may confer cardioprotection under certain conditions. |
| Databáze: | OpenAIRE |
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