Opiorphin levels in fluids of burning mouth syndrome patients: a case-control study
| Autor: | Adeline Braud, Yves Boucher, Evelyne Dufour, Catherine Ottone, Catherine Rougeot, M.T. Guinnepain, Vianney Descroix, Marie-Noëlle Ungeheuer, Vanessa Baaroun, Scarlette Agbo-Godeau |
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| Rok vydání: | 2016 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty Pathology Saliva Urinary system education Analgesic Enzyme-Linked Immunosorbent Assay Burning Mouth Syndrome Gastroenterology 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine Internal medicine Statistical significance parasitic diseases medicine Humans Salivary Proteins and Peptides General Dentistry Chromatography High Pressure Liquid Pain Measurement business.industry Opiorphin Case-control study 030206 dentistry Middle Aged Burning mouth syndrome Case-Control Studies Female medicine.symptom business Oligopeptides Biomarkers 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Clinical Oral Investigations. 21:2157-2164 |
| ISSN: | 1436-3771 1432-6981 |
| DOI: | 10.1007/s00784-016-1991-0 |
| Popis: | Idiopathic Burning mouth syndrome (iBMS) is a poorly understood affection characterized by persistent pain in the oral cavity without any clinical or biological abnormality. Opiorphin is a natural inhibitor of enkephalin-inactivating ectopeptidases, mainly produced by salivary glands, that has demonstrated analgesic properties. The objective of the present case-control study was to test the hypothesis of a decrease in opiorphin levels in iBMS patients. Twenty-one iBMS patients and 21 matched controls subjects were included between 2011 and 2013. Submandibular and sublingual salivary, blood, and urinary opiorphin levels of iBMS patients were compared to controls. Results are expressed as mean values ± SD and compared using the Wilcoxon Signed Rank test. Correlations were analyzed with Spearman coefficient. The level of significance was fixed at p |
| Databáze: | OpenAIRE |
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