Differential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cord☆
| Autor: | David J. Cutler, Shelagh Wilson, Ron A. Leslie, Sara Patel, Gareth Williams, Richard Morris, Robin E. Buckingham, Jonathan R.S. Arch, Vimal Sheridhar, Trevor A. Wattam, Martyn L. Evans, Stephen Dudley Holmes |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Physiology Molecular Sequence Data Thalamus Hypothalamus Biology Biochemistry Eating Cellular and Molecular Neuroscience Orexin-A Endocrinology Antibody Specificity Internal medicine mental disorders medicine Animals Tissue Distribution Amino Acid Sequence Rats Wistar Orexins Neuropeptides digestive oral and skin physiology Intracellular Signaling Peptides and Proteins Brain Spinal cord Immunohistochemistry Rats Peripheral Orexin medicine.anatomical_structure Spinal Cord nervous system Locus coeruleus Carrier Proteins Neuroscience psychological phenomena and processes hormones hormone substitutes and hormone antagonists |
| Zdroj: | Peptides. 20:1455-1470 |
| ISSN: | 0196-9781 |
| Popis: | The orexins are recently identified appetite-stimulating hypothalamic peptides. We used immunohistochemistry to map orexin-A and orexin-B immunoreactivity in rat brain, spinal cord, and some peripheral tissues. Orexin-A- and orexin-B-immunoreactive cell bodies were confined to the lateral hypothalamic area and perifornical nuclei. Orexin-A-immunoreactive fibers were densely distributed in the hypothalamus, septum, thalamus, locus coeruleus, spinal cord, and near the ventricles, but absent from peripheral sites investigated. In contrast, orexin-B-immunoreactive fibers were distributed sparsely in the hypothalamus. Orexin cells are strategically sited to contribute to feeding regulation, but their widespread projections suggest that orexins have other physiological roles. |
| Databáze: | OpenAIRE |
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