Retinal Lineage Therapeutic Specific Effect of Human Orbital and Abdominal Adipose-Derived Mesenchymal Stem Cells
| Autor: | Shira Weisthal Algor, Oded Ohana, Itay Nakdimon, Shay Keren, Igal Leibovitch, Ayala Elhikis, Ran Ben Cnaan, Moshe Benhamou, Aya Barzelay, Bryan Krief, Anouk Savir Kadmon, Adiel Barak, Anat Loewenstein, Ilan Feldman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Retinal degeneration
Programmed cell death Pathology medicine.medical_specialty Article Subject business.industry Mesenchymal stem cell Adipose tissue Retinal Cell Biology medicine.disease RC31-1245 Embryonic stem cell Transplantation chemistry.chemical_compound chemistry medicine sense organs business Internal medicine Molecular Biology Research Article Retinal regeneration |
| Zdroj: | Stem Cells International, Vol 2021 (2021) Stem Cells International |
| ISSN: | 1687-9678 1687-966X |
| DOI: | 10.1155/2021/7022247 |
| Popis: | Retinal degenerative diseases are one of the main causes of complete blindness in aged population. In this study, we compared the therapeutic potential for retinal degeneration of human mesenchymal stem cells derived from abdominal subcutaneous fat (ABASCs) or from orbital fat (OASCs) due to their accessibility and mutual embryonic origin with retinal tissue, respectively. OASCs were found to protect RPE cells from cell death and were demonstrated to increase early RPE precursor markers, while ABASCs showed a raise in retinal precursor marker expression. Subretinal transplantation of OASCs in a mouse model of retinal degeneration led to restoration of the RPE layer while transplantation of ABASCs resulted in a significant restoration of the photoreceptor layer. Taken together, we demonstrated a lineage-specific therapeutic effect for either OASCs or ABASCs in retinal regeneration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|