Iodine-125 radioactive seed tissue implantation as a remedy treatment for recurrent cervical cancer
| Autor: | Lei Han, Xiao Zhang, Jundong Yang, Junye Wang, Changlun Li, Xueqi He, Guofeng Liu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine medicine.medical_specialty Radioactive seed medicine.medical_treatment Brachytherapy Uterine Cervical Neoplasms Recurrent cervical cancer Salvage therapy chemistry.chemical_element Iodine lcsh:RC254-282 Iodine Radioisotopes 03 medical and health sciences Postoperative Complications 0302 clinical medicine medicine Humans Radiology Nuclear Medicine and imaging Aged Neoplasm Staging Salvage Therapy Cervical cancer medicine.diagnostic_test tissue implantation business.industry General Medicine Middle Aged lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Surgery Treatment Outcome 030104 developmental biology Oncology chemistry radioactive seeds Positron emission tomography Positron-Emission Tomography 030220 oncology & carcinogenesis Female Neoplasm Recurrence Local Tomography X-Ray Computed business Progressive disease Follow-Up Studies |
| Zdroj: | Journal of Cancer Research and Therapeutics, Vol 12, Iss 7, Pp 176-180 (2016) |
| ISSN: | 0973-1482 |
| DOI: | 10.4103/0973-1482.200611 |
| Popis: | Purpose: This study was designed to discuss feasibility, short-term efficacy, and complications of iodine-125 radioactive seed tissue implantation for remedying recurrent cervical cancer. Materials and Methods: From June 2009 to December 2010, 17 patients with recurrent cervical cancer received radioactive seed implantation under computed tomography (CT) guidance. Matched peripheral dose was 145 Gy, while the number of implanted seeds was from 6 to 68 with a median of 20. Efficacy was determined based on the results of CT and 18 F-fluorodeoxyglucose positron emission tomography/CT. Results: Postoperative follow-ups were from 4 to 18 months with a median follow-up time of 9.5 months. Nine patients died during follow-up while remaining patients survived during the follow-up period. Evaluation of efficacy: six patients had a complete response, four patients had a partial response, and seven patients had progressive disease, clinical efficacy rate as 58% (10/17). No patients had complications of radiation injury. Rate of 6 months and 1-year survival period was 74.8% and 18.3%, respectively. Comparing to patients who responded ineffectively to radioactive seed implantation, patients who responded effectively to radioactive seed implantation had a longer survival period (median 7.2 vs. median 10.4), in which the difference was statistically significant (P = 0.038). Conclusion: Iodine-125 radioactive seed tissue implantation is a feasible, effective, and safe treatment method for remedying or palliative treatment of recurrent cervical cancer. Patients who have recurrent cervical cancer and responded effectively to radioactive seed implantation will have a longer survival period. |
| Databáze: | OpenAIRE |
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