Can healthy lifestyle reduce disease progression of Alzheimer’s during a global pandemic of COVID-19?

Autor: Kiran Ali, P. Hemachandra Reddy, Albin John, Harrison Marsh
Rok vydání: 2021
Předmět:
COX
cytochrome c oxidase activity

Aging
HIF-α
hypoxia inducible factor-Iα

PS2
presenilin 2

Review

amyloid beta

Disease
Biochemistry
Diabetes mellitus
RAAS
renin-angiotensin-aldosterone system

ROS
reactive oxidative species

Pandemic
Vector (molecular biology)
TMPRSS2
transmembrane protease serine 2

APP
amyloid beta precursor protein

TNF-α
tumor necrosis factor α

COVID-19
coronavirus disease 2019

PS1
presenilin 1

WD
Western diet

ACE2
angiotensin converting enzyme 2

MFRTA
mitochondrial free radical theory of aging

Neurology
MCI
mild cognitive impairment

Hypertension
Disease Progression
APOE4
apolipoprotein E4 genotype

ORF
open-reading frames

SCD
sickle cell disease

Alzheimer's disease
Alzheimer’s disease
PARP
poly-ADP-ribose polymerase

Biotechnology
medicine.medical_specialty
T2D
type 2 diabetes

AD
Alzheimer’s disease

BMI
body metabolic index

CNS
central nervous system

SARS-CoV-2
severe acute respiratory syndrome coronavirus 2

CypD
cyclophilin D

MitomiRs
mitochondrial microRNAs

MtDNA
mitochondrial DNA

NPIQ
neuropsychiatric Inventory-Questionnaire

Alzheimer Disease
medicine
Humans
Dementia
IFN
interferon

Obesity
Healthy Lifestyle
Intensive care medicine
MHV
mouse hepatitis virus

Pandemics
Molecular Biology
Aged
NO
nitric oxide

SARS-CoV-2
business.industry
Amyloid beta
COVID-19
Lifestyle
medicine.disease
DMV
double membrane vesicles

Pneumonia
TyG
triglyceride and glucose index

Amyloid precursor protein
business
Zdroj: Ageing Research Reviews
ISSN: 1568-1637
DOI: 10.1016/j.arr.2021.101406
Popis: The novel coronavirus disease 2019 (COVID-19) has pushed the medical system to its breaking point. While the virus does not discriminate, the elderly and those with comorbidities, including hypertension severe obesity, diabetes mellitus, coronary disease, pneumonia and dementia, are at a greater risk for adverse outcomes due to COVID-19. While many people navigate their new normal, the question of what the long-lasting effects of the pandemic may be, lingers. To investigate how vulnerable populations are affected by the pandemic, we focused on Alzheimer's disease, a vector to understanding how the virus has impacted AD progression and risk via aging. By assessing the effect of COVID-19 on AD patients, we explore genetics, metabolism, and lifestyle factors in both COVID-19 and Alzheimer's disease that can work synergistically to precipitate adverse outcomes. This article also discusses how age-related conditions and/or age-related comorbidities susceptible to COVID-19. We also discuss possible healthy lifestyle factors reduce and/or combat COVID-19 now and in the future.
Databáze: OpenAIRE