Homoserine and Threonine Peptide Assembly
| Autor: | Michael C. Pirrung, Nicole A. Bakas |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
amino acids 010405 organic chemistry Stereochemistry Organic Chemistry Homoserine Peptide 010402 general chemistry 01 natural sciences 0104 chemical sciences Amino acid Serine Acylation amides chemistry.chemical_compound chemistry trans-esterification Aspartic acid Nucleophilic substitution acylation Threonine nucleophilic substitution |
| Zdroj: | Pirrung, MC; & Bakas, NA. (2018). Homoserine and Threonine Peptide Assembly. SYNLETT, 29(2), 238-242. doi: 10.1055/s-0036-1589123. UC Riverside: Retrieved from: http://www.escholarship.org/uc/item/94m8n58z |
| Popis: | Drawing on our recent success with reagent-less peptide-bond formation through serine-based assembly reactions in organic solvent, their range has been expanded to threonine and homoserine (an aspartic acid precursor) in the N-terminal peptide. Amino acid scope available at the assembly C-terminus includes bulky residues not amenable to classical ligation methods, such as cysteine-based NCL in aqueous media. The method was used to assemble a snakebite-toxin-neutralizing peptide from opossums. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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