COVID-19 Infection in Pregnancy: PCR Cycle Thresholds, Placental Pathology, and Perinatal Outcomes
| Autor: | María Yolotzin Valdespino-Vázquez, María de Lourdes Gómez-Sousa, Salvador Espino-Y-Sosa, Mario Solis-Paredes, Irma A. Coronado-Zarco, Juan Carlos Rodriguez-Aldama, Carolina Valencia-Contreras, Guadalupe Estrada-Gutierrez, Claudine Irles, Ricardo Figueroa-Damián, Estibalitz Laresgoiti-Servitje, Rosa Gabriela Hernández-Cruz, Manuel Cortés-Bonilla, Moisés León-Juárez, Mónica Aguinaga-Ríos, Elsa Romelia Moreno-Verduzco, Maria Antonieta Rivera-Rueda, Rafael Galván-Contreras, Jorge Arturo Cardona-Pérez, Alejandro Ortiz-Calvillo, Isabel Villegas-Mota, Addy Cecilia Helguera-Repetto, Sandra Acevedo-Gallegos, Mario Rodríguez-Bosch |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty placenta Biopsy Context (language use) Logistic regression Polymerase Chain Reaction Microbiology Article Preeclampsia Young Adult Virology Placenta Humans Medicine hypertensive disorder Pregnancy Complications Infectious Young adult Retrospective Studies Pregnancy medicine.diagnostic_test business.industry Obstetrics SARS-CoV-2 Pregnancy Outcome COVID-19 Retrospective cohort study medicine.disease Immunohistochemistry Infectious Disease Transmission Vertical QR1-502 Infectious Diseases medicine.anatomical_structure Female pregnancy business |
| Zdroj: | Viruses, Vol 13, Iss 1884, p 1884 (2021) Viruses Volume 13 Issue 9 |
| ISSN: | 1999-4915 |
| Popis: | (1) This study aimed to evaluate characteristics, perinatal outcomes, and placental pathology of pregnant women with or without SARS-CoV-2 infection in the context of maternal PCR cycle threshold (CT) values. (2) This was a retrospective case-control study in a third-level health center in Mexico City with universal screening by RT-qPCR. The association of COVID-19 manifestations, preeclampsia, and preterm birth with maternal variables and CT values were assessed by logistic regression models and decision trees. (3) Accordingly, 828 and 298 women had a negative and positive test, respectively. Of those positive, only 2.6% of them presented mild to moderate symptoms. Clinical characteristics between both groups of women were similar. No associations between CT values were found for maternal features, such as pre-gestational BMI, age, and symptomatology. A significantly higher percentage of placental fibrinoid was seen with women with low CTs (< 25 p < 0.01). Regarding perinatal outcomes, preeclampsia was found to be significantly associated with symptomatology but not with risk factors or CT values (p < 0.01, aOR = 14.72). Moreover, 88.9% of women diagnosed with COVID-19 at < 35 gestational weeks and symptomatic developed preeclampsia. (4) The data support strong guidance for pregnancies with SARS-CoV-2 infection, in particular preeclampsia and placental pathology, which need further investigation. |
| Databáze: | OpenAIRE |
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