Ghrelin, leptin and high-molecular-weight adiponectin in relation to depressive symptoms in older adults: Results from the Longitudinal Aging Study Amsterdam
| Autor: | Merel van Andel, Annemieke C. Heijboer, Nicole C.M. Korten, Madeleine L. Drent, Natasja M. van Schoor |
|---|---|
| Přispěvatelé: | Laboratory for Endocrinology, Amsterdam Gastroenterology Endocrinology Metabolism, Internal medicine, Epidemiology and Data Science, APH - Aging & Later Life, APH - Personalized Medicine, Psychiatry, Laboratory Medicine, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Mental Health |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
Leptin medicine.medical_specialty Aging Logistic regression High-molecular-weight adiponectin Weight loss Internal medicine CES-D score medicine Humans Older adult Depression (differential diagnoses) Depressive symptoms Aged Netherlands Aged 80 and over Adiponectin business.industry Depression digestive oral and skin physiology Middle Aged Ghrelin Psychiatry and Mental health Clinical Psychology Cohort Female medicine.symptom business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of affective disorders, 296, 103-110. Elsevier van Andel, M, van Schoor, N M, Korten, N C, Heijboer, A C & Drent, M L 2022, ' Ghrelin, leptin and high-molecular-weight adiponectin in relation to depressive symptoms in older adults : Results from the Longitudinal Aging Study Amsterdam ', Journal of Affective Disorders, vol. 296, pp. 103-110 . https://doi.org/10.1016/j.jad.2021.09.069 Journal of Affective Disorders, 296, 103-110. Elsevier |
| ISSN: | 0165-0327 |
| Popis: | Background: Ghrelin, leptin and high-molecular-weight (HMW) adiponectin have been linked to depression in middle-aged adults. Pathophysiological mechanisms of depression change as age progresses and it is unclear whether the same associations exist in older adults. Methods: We analyzed the associations between ghrelin, leptin and HMW adiponectin and depressive symptoms (Center for Epidemiologic Studies Depression (CES-D) score ≥ 16) in a community-dwelling cohort of 898 participants in a multivariable logistic regression analysis at baseline and after three years of follow-up, were applicable stratified by sex, age and waist-hip-ratio (WHR). Results: At baseline no significant associations were found. After three years of follow-up ghrelin was associated with higher odds for depressive symptoms (fully adjusted continuous analysis OR 2.27, 95% CI 1.42 – 3.61). There was effect modification for age and WHR, with significant associations in participants younger than 69.7 years (median) and with a WHR below 0.9554 (mean). In the sex-stratified analysis for leptin we found significant associations in men (fully adjusted continuous analysis OR 1.07, 95% CI 1.02 – 1.12). For HMW adiponectin there were no significant associations in the multivariable analysis. Limitations: As our cohort consisted of relatively healthy participants with intact cognitive function, selection bias may have contributed to lack of significant baseline associations. Conclusions: Our results show significant associations between ghrelin and – for men only - leptin and depressive symptoms after three years of follow up. This may provide a new therapeutic window for treatment of depressive symptoms in older adults, as both ghrelin and leptin are positively influenced by weight loss. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect