Identification of prion protein gene polymorphisms in goats from Italian scrapie outbreaks
| Autor: | Pier Luigi Acutis, Maria Caramelli, Maria Mazza, Alex Bossers, Cristina Casalone, J. Priem, Maria Vittoria Riina, Simone Peletto, Gianluigi Forloni, Giuseppe Ru |
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| Rok vydání: | 2006 |
| Předmět: |
Silent mutation
sheep breed Prions genotype Scrapie Biology medicine.disease_cause Disease Outbreaks Polymorphism (computer science) Virology Genotype medicine Animals Genetic Predisposition to Disease Allele CIDC - Divisie Bacteriologie en TSE's natural scrapie Gene variants Mutation Goat Diseases Polymorphism Genetic Goats allele Genetic Variation Outbreak encephalopathy ovine Italy occurs Case-Control Studies CVI - Divisie Bacteriologie en TSE's caprine prp gene |
| Zdroj: | Journal of General Virology, 87, 1029-1033 Journal of General Virology 87 (2006) |
| ISSN: | 1465-2099 0022-1317 |
| Popis: | Susceptibility to scrapie in sheep is influenced by polymorphisms of the prion protein (PrP) gene, whereas no strong association between genetics and scrapie has yet been determined in goats due to the limited number of studies on these animals. In this case–control study on 177 goats from six Italian scrapie outbreaks, the association between PrP alleles and the occurrence of scrapie was studied. Three silent mutations and 11 PrP polymorphisms were identified, of which two polymorphisms (L133Q and M137I) and one silent mutation (T202T) have not been reported previously. Twelve alleles were determined by cloning. Statistical analysis suggested a possible protective role against scrapie for the glutamine to lysine mutation at codon 222. |
| Databáze: | OpenAIRE |
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