Effect of Trimetazidine on Retinal Ischemia/Reperfusion Injury in Rats

Autor: Sevda Muftuoglu, Bahriye Kildaci, Serap Özden, Nur Çakar, Cem Yildirim
Rok vydání: 2001
Předmět:
Retinal ischemia/reperfusion
cell protection
trimetazidine
Animals
Antioxidants/*pharmacology
Cytoprotection/drug effects
Models
Animal
Rats
Rats
Wistar
Reperfusion Injury/pathology/*prevention & control
Retina/*drug effects/injuries/ultrastructure
Trimetazidine/*pharmacology
medicine.medical_treatment
animal experiment
Trimetazidine
Ischemia
Pharmacology
Antioxidants
Retina
retinal ischemia/reperfusion
rat retina
chemistry.chemical_compound
Rat retina
medicine
controlled study
rat
Saline
Chemotherapy
nonhuman
retina ischemia
business.industry
Vascular disease
article
Retinal
General Medicine
reperfusion injury
medicine.disease
Sensory Systems
retina injury
Ophthalmology
medicine.anatomical_structure
chemistry
Cytoprotection
retina bipolar ganglion cell
Anesthesia
histopathology
business
Reperfusion injury
medicine.drug
Zdroj: Ophthalmologica. 215:309-317
ISSN: 1423-0267
0030-3755
Popis: Purpose: To investigate the effect of trimetazidine (TMZ), an antioxidant agent, on the ischemia/reperfusion (I/R) injury in rat retina histopathologically. Methods: The retinal I/R model was carried out by the 4-vessel occlusion method on Wistar albino rats. Twenty-one rats were divided into 7 groups, each comprising 3 rats. The animals in groups 1, 2 and 3 underwent 30 min of ischemia + 4 h of reperfusion and were treated by the administration of saline, TMZ before reperfusion and TMZ before ischemia, respectively. The animals in groups 4, 5 and 6 underwent 90 min of ischemia + 4 h of reperfusion and were treated in the same way as those in groups 1, 2 and 3, respectively. The 7th group was sham operated. Results: Thirty and 90 min of ischemia followed by 4 h of reperfusion induced retinal injury in the rat retina. Histopathologically, the inner plexiform and inner nuclear layers were the most affected parts. TMZ was able to reduce almost all retinal I/R damage when administered before ischemia. A cytoprotective effect of TMZ was partly observed in those animals which were treated before reperfusion. Conclusion: TMZ seemed to have a protective effect against retinal I/R injury in rats.
Databáze: OpenAIRE
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