A Prospective Observational Study of 42 Patients with COVID-19 infection and a History of Hepatitis C Virus Infection and Thyroid Disease with Follow-Up Thyroid Function and Autoantibody Testing
| Autor: | Badiu, Dumitru Cristinel, Popescu, Gabriel Cristian, Zgura, Anca, Stanciu, Adriana Mercan, Dodot, Mihai Daniel, Mehedintu, Claudia, Toma, Letitia, Razvan, Simu, Bacinschi, Xenia, Haineala, Bogdan |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male endocrine system endocrine system diseases ACE2 Protein Human Thyroid Gland Thyrotropin Hepacivirus Thyroid Function Tests Hypothyroidism Clinical Research Humans Prospective Studies Aged Romania SARS-CoV-2 Thyroiditis Autoimmune COVID-19 General Medicine Hepatitis C Chronic Middle Aged Thyroid Diseases Hepatitis C Thyroxine RNA Viral Triiodothyronine Female Follow-Up Studies |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.935075 |
| Popis: | BACKGROUND Thyroiditis is an important extrahepatic association in chronic hepatitis C virus (HCV) infection. There have been reports of an association between SARS-CoV-2 infection and the onset or re-activation of autoimmune hypothyroidism. Therefore, we performed this prospective observational study of 42 patients with COVID-19 infection and a history of hepatitis C virus infection and thyroid disease with follow-up thyroid function and autoantibody testing. MATERIAL AND METHODS From April 2020 to October 2020, we performed a prospective observational study of patients with cured hepatitis C virus (HCV) infection and documented thyroid disease who became infected with SARS-CoV-2 (confirmed by SARS-CoV-2 RNA detection via reverse-transcription polymerase chain reaction [RT-PCT] from the upper respiratory tract, both nasal and pharyngeal swabs). Evaluation at 1 and 3 months after SARS-CoV-2 infection included serum determination of antithyroid antibodies (anti-thyroglobulin [anti-Tg] and antithyroid peroxidase [ATPO]), thyroid-stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3), and evaluation of thyroid medication, with dose adjustment if required. RESULTS One-month follow-up showed that both patients with autoimmune thyroiditis as well as patients without antibodies had increased ATPO levels. Also, levels of TSH, fT3, and fT4 were significantly decreased. At 3-month follow-up, levels of ATPO were decreased in all patient groups and the levels of thyroid hormones increased to normal values. CONCLUSIONS This study supports previous reports of an association between SARS-CoV-2 infection and thyroid dysfunction associated with thyroid autoantibodies. Thyroid function tests may be considered as part of the laboratory work-up in patients with COVID-19. |
| Databáze: | OpenAIRE |
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