Effects of dietary milk- and soy phospholipids on lipid-parameters and other risk indicators for cardiovascular diseases in overweight or obese men : two double-blind, randomised, controlled, clinical trials
| Autor: | Achim Bub, Maria Pfeuffer, Juergen Schrezenmeir, Anne Weiland, Stephan Barth |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Apolipoprotein B Endocrinology Diabetes and Metabolism medicine.medical_treatment soya phospholipids Overweight PC phosphatidylcholine fluids and secretions AST aspartate transaminase ddc:796 Nutrition and Dietetics biology Fatty liver food and beverages CVD PL phospholipid Athletic & outdoor sports & games CRP C-reactive protein lipids (amino acids peptides and proteins) medicine.symptom MTHFR methylenetetrahydrofolate reductase Research Article medicine.medical_specialty Waist milk phospholipids ALT alanine transaminase Aspartate transaminase HOMA-IR homeostasis model assessment of insulin resistance tHcy total homocysteine 03 medical and health sciences GGT γ-glutamyl transferase Internal medicine plasma lipids medicine human nutrition 030109 nutrition & dietetics SM sphingomyelin business.industry Insulin HDL-C HDL-cholesterol C-reactive protein MFGM milk fat globule membrane LDL-C LDL-cholesterol medicine.disease TC total cholesterol Endocrinology Alanine transaminase biology.protein business Food Science |
| Zdroj: | Journal of nutritional science, 5 (e21), 1-9 Journal of Nutritional Science |
| ISSN: | 2048-6790 |
| Popis: | The present study examined the effect of milk phospholipids (milk-PL) on lipid metabolism and on other risk factors for CVD, in comparison with milk fat (control) or soya phospholipids (soya-PL), respectively. Two double-blind parallel-group intervention trials were conducted in overweight or obese male subjects. In the first trial (trial 1), sixty-two men consumed milk enriched with either 2 g milk-PL or 2 g milk fat (control) for 8 weeks. In trial 2, fifty-seven men consumed milk enriched with either 3 g milk-PL or 2·8 g soya-PL for 7 weeks. In trial 1, milk-PL as compared with control reduced waist circumference but did not affect plasma lipids (total, HDL- and LDL-cholesterol, total cholesterol:HDL-cholesterol ratio, TAG, phospholipids), apoB, apoA1, glucose, insulin, insulin sensitivity index, C-reactive protein, IL-6, soluble intracellular adhesion molecule and total homocysteine (tHcy). Serum activities of alanine transaminase and aspartate transaminase were not changed. Activity of γ-glutamyl transferase (GGT), a marker of fatty liver, increased in the control but not in the milk-PL group, with a significant intervention effect. In trial 2, milk-PL as compared with soya-PL did not affect the above-mentioned parameters, but decreased GGT. Subjects with the methylenetetrahydrofolate reductase mutations CT and TT had 11 % (P |
| Databáze: | OpenAIRE |
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