Sex steroid modulation of neurokinin B gene expression in the arcuate nucleus of adult male rats
| Autor: | Nathaniel T. McMullen, Steve C. Danzer, Naomi E. Rance, Robin O. Price |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Antineoplastic Agents Hormonal medicine.drug_class Neurokinin B Neuropeptide Gene Expression Galanin Biology Rats Sprague-Dawley Cellular and Molecular Neuroscience chemistry.chemical_compound Arcuate nucleus Internal medicine medicine Animals Testosterone RNA Messenger Molecular Biology Brain Chemistry Age Factors Arcuate Nucleus of Hypothalamus Estrogens Androgen Rats Endocrinology medicine.anatomical_structure nervous system chemistry Sex steroid Hypothalamus Nucleus Orchiectomy |
| Zdroj: | Brain research. Molecular brain research. 66(1-2) |
| ISSN: | 0169-328X |
| Popis: | Human menopause is associated with hypertrophy and increased gene expression of neurokinin (NKB) neurons in the infundibular (arcuate) nucleus of the hypothalamus. We have hypothesized that these changes are secondary to gonadal failure. In the present study, we determined that orchidectomy resulted in an increase in the mean profile area and the number of neurons expressing NKB mRNA in the rat arcuate nucleus. No changes were seen when orchidectomy was combined with testosterone or estradiol replacement. These findings support our hypothesis and demonstrate that gonadal steroids modulate NKB neurons in the arcuate nucleus of adult male rats. |
| Databáze: | OpenAIRE |
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