Establishment of PANDA - a new human pancreatic ductal adenocarcinoma cell line with 3D cell culture technology
| Autor: | Ivan Kapralik, J Janik, Hugo Maurice Dumortier, Michael Bouvet, Dusan Brany, Dusan Loderer, Miroslav Pindura, Barbora Mitruskova, Henrieta Škovierová, Erika Halasova, Marian Grendar, Blazej Palkoci, Martin Kertys, Lukáš Plank, Mark A. Valasek, Juraj Mokry, Tomas Chromec, Martin Vojtko, Slavomíra Nováková, Michal Kalman, Juraj Marcinek, Sandra Mersakova, Roman Kycina, Laca L, Romana Zahumenska, Jan Strnadel |
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| Rok vydání: | 2022 |
| Předmět: |
Technology
Cancer Research Chemotherapy Pancreatic ductal adenocarcinoma business.industry medicine.medical_treatment Cancer Adenocarcinoma medicine.disease Malignancy digestive system diseases Cell Line Pancreatic Neoplasms Radiation therapy 3D cell culture Oncology In vivo Cell culture Cancer research Humans Medicine Cell Culture Techniques Three Dimensional business |
| Zdroj: | Neoplasma. 69:165-173 |
| ISSN: | 1338-4317 |
| Popis: | Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive type of malignancy with one of the worst prognoses amongst any type of cancer. Surgery is applicable only to the limited number of patients with locally resectable tumors and currently represents the only curative treatment option. Treatment with chemotherapy and radiotherapy can only extend patient survival. Despite advances in conventional therapies, the five-year survival of PDAC remained largely unchanged. New in vitro and in vivo models are therefore urgently needed to investigate this type of cancer. Here, we present the establishment and characterization of a novel pancreatic cancer cell line, isolated from a patient with PDAC. Cell line abbreviated as PANDA (PANncreatic Ductal Adenocarcinoma) was established with an optimized 3D culture protocol published previously by our group. The new cancer cell line "PANDA" represents a novel in vitro approach for PDAC cancer research and new therapy testing. |
| Databáze: | OpenAIRE |
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