Peripheral blood stem cell collection in elderly patients

Autor: Ljubomir Petrov, Francoise Quivoron, Adrian Tempescul, Jean-Christophe Ianotto, Christian Berthou, Elisabeth Hardy
Přispěvatelé: Immunologie et Pathologie (EA2216), Université de Brest (UBO)-IFR148, Service Hématologie, Hôpital Morvan [Brest]-Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), ONERA - The French Aerospace Lab [Châtillon], ONERA-Université Paris Saclay (COmUE), EFS Bretagne, Université européenne de Bretagne - European University of Brittany (UEB), Michel, Geneviève
Rok vydání: 2009
Předmět:
medicine.medical_specialty
[SDV.IMM] Life Sciences [q-bio]/Immunology
Lymphoma
CD34
Antigens
CD34
Cell Count
MESH: Multiple Myeloma
MESH: Peripheral Blood Stem Cell Transplantation
Peripheral Blood Stem Cells
MESH: Hematopoietic Stem Cell Mobilization
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Aged
Retrospective Studies
MESH: Age Factors
MESH: Aged
Peripheral Blood Stem Cell Transplantation
MESH: Humans
Hematology
MESH: Cell Count
business.industry
Age Factors
MESH: Retrospective Studies
Retrospective cohort study
MESH: Antigens
CD34
General Medicine
medicine.disease
Hematopoietic Stem Cell Mobilization
3. Good health
Surgery
MESH: Blood Component Removal
Apheresis
Peripheral blood stem cell collection
030220 oncology & carcinogenesis
Blood Component Removal
Feasibility Studies
[SDV.IMM]Life Sciences [q-bio]/Immunology
Stem cell
Multiple Myeloma
MESH: Feasibility Studies
MESH: Lymphoma
business
030215 immunology
Zdroj: Annals of Hematology
Annals of Hematology, Springer Verlag, 2010, 89 (3), pp.317-21
ISSN: 1432-0584
0939-5555
DOI: 10.1007/s00277-009-0812-9
Popis: International audience; Intensive treatments like autologous blood stem cell transplantations are standard consolidation treatments for lymphoma and myeloma in young people. The upper age limit for these procedures is constantly increasing. Instead of studying the impact of aging on harvesting peripheral blood stem cells (PBSC), we performed a retrospective study to explore the feasibility of collecting stem cells from patients older than 65 years and compared the efficacy to harvest in younger patients. During a period of 7 years, we identified 108 patients with myeloma or lymphoma who were older than 65 years who underwent PBSC collection. Only eight patients failed to produce a successful harvest. The majority of patients only needed one apheresis (71%). There was a median number of 5.3 x 10(6) CD34+ cells/kg. Our study demonstrated that older patients can also undergo PBSC harvests similar to younger patients.
Databáze: OpenAIRE
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