Mild Respiratory Illness Among Young Children Caused by Highly Pathogenic Avian Influenza A (H5N1) Virus Infection in Dhaka, Bangladesh, 2011
| Autor: | Apurba Chakraborty, Stephen P. Luby, Rebeca Sultana, Mustafizur Rahman, Katharine Sturm-Ramirez, Doli Goswami, Najmul Haider, Nancy A. Gerloff, Timothy M. Uyeki, Abdullah Al Mamun, Andrea Mikolon, Nusrat Homaira, M. Sabbir Haider, Natosha Simpson, Salah Uddin Khan, Ausraful Islam, Mahmudur Rahman, M. Saiful Islam, I. S. Shanta, Bo Shu, C. Todd Davis, Eduardo Azziz-Baumgartner, Nadia Ali Rimi, M. Jahangir Hossain, Jaqueline M. Katz, Asm Alamgir, Khondokar Mahbuba Jamil, Tahmina Sultana, Stephen Lindstrom, Kamrun Nahar |
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| Rok vydání: | 2017 |
| Předmět: |
Male
030231 tropical medicine Population Orthomyxoviridae Animals Wild Biology medicine.disease_cause Poultry Disease Outbreaks Specimen Handling 03 medical and health sciences Feces 0302 clinical medicine Blood serum Surveys and Questionnaires Influenza A virus medicine Immunology and Allergy Animals Humans 030212 general & internal medicine education Respiratory Tract Infections education.field_of_study Bangladesh Hemagglutination assay Influenza A Virus H5N1 Subtype Transmission (medicine) Viral culture Infant biology.organism_classification Virology Influenza A virus subtype H5N1 Infectious Diseases Child Preschool Influenza in Birds Population Surveillance Female Follow-Up Studies |
| Zdroj: | The Journal of infectious diseases. 216(suppl_4) |
| ISSN: | 1537-6613 |
| Popis: | Background In March 2011, a multidisciplinary team investigated 2 human cases of highly pathogenic avian influenza A(H5N1) virus infection, detected through population-based active surveillance for influenza in Bangladesh, to assess transmission and contain further spread. Methods We collected clinical and exposure history of the case patients and monitored persons coming within 1 m of a case patient during their infectious period. Nasopharyngeal wash specimens from case patients and contacts were tested with real-time reverse-transcription polymerase chain reaction, and virus culture and isolates were characterized. Serum samples were tested with microneutralization and hemagglutination inhibition assays. We tested poultry, wild bird, and environmental samples from case patient households and surrounding areas for influenza viruses. Results Two previously healthy case patients, aged 13 and 31 months, had influenzalike illness and fully recovered. They had contact with poultry 7 and 10 days before illness onset, respectively. None of their 57 contacts were subsequently ill. Clade 2.2.2.1 highly pathogenic avian influenza H5N1 viruses were isolated from the case patients and from chicken fecal samples collected at the live bird markets near the patients' dwellings. Conclusion Identification of H5N1 cases through population-based surveillance suggests possible additional undetected cases throughout Bangladesh and highlights the importance of surveillance for mild respiratory illness among populations frequently exposed to infected poultry. |
| Databáze: | OpenAIRE |
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