[3H]-flunitrazepam-labeled benzodiazepine binding sites in the hippocampal formation in autism: a multiple concentration autoradiographic study
| Autor: | Margaret L. Bauman, Jeffrey T. Guptill, Gene J. Blatt, Terrell T. Gibbs, Anne B. Booker, Thomas L. Kemper |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Cerebellum Adolescent medicine.drug_class Hippocampus Flunitrazepam Hippocampal formation Benzodiazepines Receptors GABA Internal medicine Developmental and Educational Psychology medicine Humans Autistic Disorder GABA Modulators Benzodiazepine Binding Sites Ligand (biochemistry) Endocrinology medicine.anatomical_structure Nissl Bodies GABAergic Autoradiography Nerve Net Psychology Neuroscience medicine.drug |
| Zdroj: | Journal of autism and developmental disorders. 37(5) |
| ISSN: | 0162-3257 |
| Popis: | Increasing evidence indicates that the GABAergic system in cerebellar and limbic structures is affected in autism. We extended our previous study that found reduced [(3)H]flunitrazepam-labeled benzodiazepine sites in the autistic hippocampus to determine whether this reduction was due to a decrease in binding site number (B (max)) or altered affinity (K (d)) to bind to the ligand. Quantitation of hippocampal lamina demonstrated a 20% reduction in B (max) indicating a trend toward a decreased number of benzodiazepine binding sites in the autistic group but normal K (d) values. A reduction in the number of hippocampal benzodiazepine binding sites suggests alterations in the modulation of GABA(A) receptors in the presence of GABA in the autistic brain, possibly resulting in altered inhibitory functioning of hippocampal circuitry. |
| Databáze: | OpenAIRE |
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