The detection of sedatives in hair and nail samples using tandem LC-MS-MS
| Autor: | Stuart J. Dickson, Rachel C. Irving |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Triazolam Midazolam Poison control Clonazepam Mass Spectrometry Piperazines Pathology and Forensic Medicine Benzodiazepines Temazepam Predictive Value of Tests medicine Humans Hypnotics and Sedatives Forensic Pathology Prazepam Aged Zopiclone Aged 80 and over Chromatography Diazepam integumentary system Alprazolam business.industry Oxazepam Hair analysis Middle Aged Sexual abuse Nails Anesthesia Rape Clobazam Female business Law Azabicyclo Compounds medicine.drug Chromatography Liquid Hair |
| Zdroj: | Forensic science international. 166(1) |
| ISSN: | 0379-0738 |
| Popis: | Drug screening methods were developed to detect alprazolam, clobazam, clonazepam, diazepam, midazolam, oxazepam, temazepam, triazolam, zopiclone, and selected metabolites in human hair and nail samples employing liquid–liquid extraction and tandem liquid chromatography–mass spectrometry (LC–MS–MS). Hair and nail samples were obtained from patients who had recently discontinued or were currently prescribed one or more of the targeted drugs. Prazepam was used as the internal standard for all compounds. Some components in the hair matrix gave the same transitions as some of the analytes but did not compromise the analyses because their retention times differed from those for the target compounds. The analytical run time was 8–10 min. Results of the hair analysis of a DFSA victim are also presented. |
| Databáze: | OpenAIRE |
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