Right parahippocampal volume deficit in an older population with posttraumatic stress disorder
| Autor: | Janine D. Flory, Adam M. Brickman, Rachel Yehuda, Frank A. Provenzano, Bret R. Rutherford, Philip R. Szeszko, Benjamin Maas, Rakshathi Basavaraju, Yuval Neria |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Population Older population Stress Disorders Post-Traumatic 03 medical and health sciences 0302 clinical medicine medicine Humans Dementia education Pathological Biological Psychiatry Depression (differential diagnoses) Aged Veterans education.field_of_study medicine.diagnostic_test business.industry Brain Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health Posttraumatic stress Cross-Sectional Studies medicine.anatomical_structure Female business 030217 neurology & neurosurgery Parahippocampal gyrus Clinical psychology |
| Zdroj: | Journal of Psychiatric Research. 137:368-375 |
| ISSN: | 0022-3956 |
| DOI: | 10.1016/j.jpsychires.2021.03.015 |
| Popis: | Background Posttraumatic Stress Disorder (PTSD) is an increasingly prevalent condition among older adults and may escalate further as the general population including veterans from recent conflicts grow older. Despite growing evidence of higher medical comorbidity, cognitive impairment and dementia, and disability in older individuals with PTSD, there are very few studies examining brain cortical structure in this population. Hence, we examined cortical volumes in a cross-sectional study of veterans and civilians aged ≥50 years, of both sexes and exposed to trauma (interpersonal, combat, non-interpersonal). Methods Cortical volumes were obtained from T1-weighted structural MRI and compared between individuals with PTSD and Trauma Exposed Healthy Controls (TEHC) adjusting for age, sex, estimated intracranial volume, depression severity, and time elapsed since trauma exposure. Results The PTSD group (N = 55) had smaller right parahippocampal gyrus compared to TEHC (N = 36), corrected p(pFWER) = 0.034, with an effect size of 0.75 (Cohen's d), with no significant group differences in other cortical areas. Conclusions These findings are different from the structural brain findings reported in studies in younger age groups (larger parahippocampal volume in PTSD patients), suggesting a possible significant change in brain structure as PTSD patients age. These results need replication in longitudinal studies across the age-span to test whether they are neuroanatomical markers representing disease vulnerability, trauma resilience or pathological neurodegeneration associated with cognitive impairment and dementia. |
| Databáze: | OpenAIRE |
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