Dahl Salt-Sensitive Rats Excrete 25-Hydroxyvitamin D into Urine
| Autor: | Myrtle Thierry-Palmer, Akins Doherty, Mohamed A. Bayorh, Keri Griffin |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Rats Inbred Dahl Nutrition and Dietetics Chemistry Sodium Population Medicine (miscellaneous) chemistry.chemical_element Metabolism Urine Micronutrient Rats Excretion Endocrinology Internal medicine Vitamin D and neurology medicine Animals Female Sodium Chloride Dietary Vitamin D Salt intake education |
| Zdroj: | The Journal of Nutrition. 133:187-190 |
| ISSN: | 0022-3166 |
| Popis: | The plasma 25-hydroxyvitamin D concentration of Dahl salt-sensitive rats (S) is markedly decreased in response to high sodium chloride (salt) intake. We tested the hypothesis that urinary excretion is a mechanism for the decrease. Female S rats excreted 0.26 +/- 0.04 nmol 25-hydroxyvitamin D/24 h at wk 2 of high salt (80 g/kg) intake, five times that of female salt-resistant (R) rats at wk 2 of high salt intake and nine times that of S rats at wk 2 of low salt (3 g/kg) intake. The 25-hydroxyvitamin D binding activity in 24-h urine of S rats was 79 +/- 11 pmol/h at wk 2 of high salt intake, two times that in urine of S rats at wk 2 of low salt intake and > 35 times that in urine of R rats at wk 2 of low or high salt intake. We conclude that markedly decreased plasma 25-hydroxyvitamin D concentrations of S rats during high salt intake result in part from excretion of protein-bound 25-hydroxyvitamin D. Low plasma 25-hydroxyvitamin D concentrations in humans may also result in part from salt sensitivity, which is prevalent in > 50% of the United States hypertensive population. |
| Databáze: | OpenAIRE |
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