| Autor: |
Lara Stevanato, Abdel Naser Zaid, Romeo Romagnoli, Pier Giovanni Baraldi, Stefano Manfredini, R. Manservigi |
| Rok vydání: |
1998 |
| Předmět: |
|
| Zdroj: |
Scopus-Elsevier |
| ISSN: |
0732-8311 |
| DOI: |
10.1080/07328319808004307 |
| Popis: |
a new series of 6-substituted N1- and N2 -β-D-ribofuranosyl-pyrazolo[3,4-d]pyridazin-7(6H)-one derivatives (8a-g, 9b-d and 9f-g) has been prepared in the aim to explore the structure-activity relationships and improve the antiviral activity of a series of N1-and N2 -β-D-ribofuranosyl-pyrazolo[4,3-d]pyrimidin-7(6H)-one derivatives previously reported by us. The studied compounds were preliminary tested for their in vitroa antiviral activity against HSV-1. Among them 8f and 9f were found 2 fold more active than those belonging to the parent series. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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