A simultaneous [11C]raclopride positron emission tomography and functional magnetic resonance imaging investigation of striatal dopamine binding in autism
| Autor: | Ayarah Dharanikota, Joshua Bizzell, Chieh-En Jane Tseng, David Izquierdo-Garcia, Jacob M. Hooker, Paul Cernasov, Jessica L. Kinard, Eric Smith, Daniel G. Dillon, Rachel K. Greene, Rachel D. Phillips, Zibo Li, Erin Walsh, Diego A. Pizzagalli, Gabriel S. Dichter, Kinh Truong, David S. Lalush, Nicole R. Zürcher |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
genetic structures
Autism Spectrum Disorder Dopamine Precuneus Striatum Molecular neuroscience behavioral disciplines and activities Article 050105 experimental psychology lcsh:RC321-571 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Dopamine receptor D3 mental disorders medicine Humans 0501 psychology and cognitive sciences Autistic Disorder lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Biological Psychiatry Raclopride medicine.diagnostic_test Receptors Dopamine D2 business.industry Putamen 05 social sciences Autism spectrum disorders medicine.disease Magnetic Resonance Imaging Corpus Striatum Psychiatry and Mental health medicine.anatomical_structure nervous system Positron-Emission Tomography Autism Functional magnetic resonance imaging business Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021) Translational Psychiatry |
| ISSN: | 2158-3188 |
| Popis: | The social motivation hypothesis of autism posits that autism spectrum disorder (ASD) is characterized by impaired motivation to seek out social experience early in life that interferes with the development of social functioning. This framework suggests that impaired mesolimbic dopamine function underlies compromised responses to social rewards in ASD. Although this hypothesis is supported by functional magnetic resonance imaging (fMRI) studies, no molecular imaging study has evaluated striatal dopamine functioning in response to rewards in ASD. Here, we examined striatal functioning during monetary incentive processing in ASD and controls using simultaneous positron emission tomography (PET) and fMRI. Using a bolus + infusion protocol with the D2/D3 dopamine receptor antagonist [11C]raclopride, voxel-wise binding potential (BPND) was compared between groups (controls = 12, ASD = 10) in the striatum. Striatal clusters showing significant between-group BPND differences were used as seeds in whole-brain fMRI general functional connectivity analyses. Relative to controls, the ASD group demonstrated decreased phasic dopamine release to incentives in the bilateral putamen and left caudate, as well as increased functional connectivity between a PET-derived right putamen seed and the precuneus and insula. Within the ASD group, decreased phasic dopamine release in the putamen was related to poorer theory-of-mind skills. Our findings that ASD is characterized by impaired striatal phasic dopamine release to incentives provide support for the social motivation hypothesis of autism. PET-fMRI may be a suitable tool to evaluate novel ASD therapeutics targeting the striatal dopamine system. |
| Databáze: | OpenAIRE |
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