Some studies on human pulmonary mast cells obtained by bronchoalveolar lavage and by enzymic dissociation of whole lung tissue
| Autor: | K. C. Flint, K. B. P. Leung, Jonathan Brostoff, M.D. Hammond, K. Seager, N.McI. Johnson, Frederick L. Pearce, D Geraint-James, B N Hudspith |
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| Rok vydání: | 1987 |
| Předmět: |
Adult
Male Adolescent Sarcoidosis Immunology Cell Hypertonic Solutions Stimulation Bronchi Cell Separation Histamine Release chemistry.chemical_compound medicine Immunology and Allergy Humans Antiasthmatic drugs Mast Cells Therapeutic Irrigation Aged Lung medicine.diagnostic_test business.industry Prostaglandin D2 Prostaglandins D General Medicine respiratory system Immunoglobulin E Middle Aged medicine.disease Asthma respiratory tract diseases Antibodies Anti-Idiotypic Pulmonary Alveoli medicine.anatomical_structure Bronchoalveolar lavage Microbial Collagenase chemistry Female SRS-A Lung tissue business Histamine |
| Zdroj: | International archives of allergy and applied immunology. 82(3-4) |
| ISSN: | 0020-5915 |
| Popis: | Human pulmonary mast cells were obtained by bronchoalveolar lavage (BAL) and by enzymic dissociation of whole lung. The cells released histamine on immunological stimulation or on exposure to a hyperosmolar environment. Cell suspensions similarly released newly generated products of arachidonic acid metabolism. Increased numbers of mast cells were recovered by BAL of asthmatic subjects and patients suffering from sarcoidosis and these cells were hyperresponsive to immunological challenge. Mast cells recovered by BAL and enzymic dissociation were differentially inhibited by antiasthmatic drugs. These data emphasize the potential role of BAL mast cells in pulmonary diseases of diverse origin. |
| Databáze: | OpenAIRE |
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