A study of tobacco carcinogenesis, LIII: carcinogenicity of N′-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mink (Mustala vison)
Autor: | Dietrich Hoffmann, Hans K. Dahle, Abraham Rivenson, Nils Koppang |
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Rok vydání: | 1997 |
Předmět: |
Male
Nasal cavity Cancer Research medicine.medical_specialty Pathology Nitrosamines Nose Neoplasms Lethal Dose 50 chemistry.chemical_compound Internal medicine biology.animal Carcinoma medicine Animals Nitrosonornicotine Mink Carcinogen biology Chemistry Body Weight Age Factors Neoplasms Experimental medicine.disease medicine.anatomical_structure Endocrinology Oncology Nitrosamine N-Nitrosonornicotine Toxicity Carcinogens Female |
Zdroj: | Cancer Letters. 111:167-171 |
ISSN: | 0304-3835 |
Popis: | In an earlier study, young male and female mink ( Mustela vison ) were found to be highly susceptible to the carcinogenic effect of N′ -nitrosonornicotine (NNN). In this follow-up study we tested (i) the importance of the age of the animals with regard to the carcinogenic effect of NNN, (ii) the carcinogenic activity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and (iii) the combined carcinogenic effect of NNN plus NNK. (I) In the previous study, the latency of nasal tumor induction by NNN (11.9 mM) averaged 84 ± 40 weeks upon twice weekly applications, starting at the age of 3 weeks and continuing for 38 weeks. In this bioassay, giving NNN in 28 weeks but starting at the age of 3 months, it took, on the average. 97 ± 29 weeks to induce malignant nasal tumors, primarily esthesioneuroepithelioma with invasion of the brain, (ii) NNK (6.3 mM), given by s.c. injection, induced nasal carcinoma with invasion of the forebrain after 77 ± 39 weeks. (iii) NNN (11.9 mM) plus NNK (6.3 mM) led to the same type of carcinoma but at an accelerated pace, namely after 71 ± 57 weeks. This study supports the earlier observation that tobacco-specific N -nitrosamines induce malignant tumors of the nasal cavity with invasion of the brain, dependent to some degree on the age of the mink at first application. NNK appears to be a stronger carcinogen than NNN in mink which follows the observations made with mice, rats and hamsters. It is suggested that combined administration of NNN with NNK induces a stronger carcinogenic effect than NNN or NNK given alone. |
Databáze: | OpenAIRE |
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