Dark tea extracts: Chemical constituents and modulatory effect on gastrointestinal function
| Autor: | Yu-xin Song, Xiang-lan Wu, Chen-jie Zhao, Wan Zhu, Jing-chi Zhang, Zhi-ping Gong, Feng Miao, Jianan Huang, Zeng Xin, Dan-Ming Lu, Mingzhi Zhu, Zhonghua Liu, Haiyan Lin, Shuxian Cai, Qi-ye Wang, Neng-xin Li, Jian Ouyang, Fang Zhou, Chun-fang Liu, Yi-Long Li |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Ileum Intestinal microbes RM1-950 complex mixtures Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lactobacillus medicine Animals Food science Gallic acid Bifidobacterium Pharmacology Tea biology Plant Extracts Microbiota Antibiotic food and beverages General Medicine biology.organism_classification medicine.disease Gastrointestinal function 030104 developmental biology medicine.anatomical_structure chemistry Polyphenol Dark tea Gastrointestinal transit Restoration 030220 oncology & carcinogenesis Dysbiosis Fermentation Therapeutics. Pharmacology |
| Zdroj: | Biomedicine & Pharmacotherapy, Vol 130, Iss, Pp 110514-(2020) |
| ISSN: | 0753-3322 |
| Popis: | Processing of dark tea varieties, such as Fu brick tea, Liupao tea, Qianliang tea, and Qing brick tea, includes solid-state fermentation involving microorganisms. In this study, we analyzed the major chemical constituents of dark tea extracts and evaluated their modulatory effect on the gastrointestinal function in normal mice, including the improvement of gastrointestinal transit and intestinal microbial, as well as the attenuation of intestinal microbial dysbiosis and intestinal pathological damage, and the adjustment of immune function in antibiotic-treated mice. Substantial differences in major chemical constituents, including total polyphenols, total organic acids, water extract content, 18 free amino acids, gallic acid, and six tea catechins, were observed among Fu brick tea, Qianliang tea, Qing brick tea, and Liupao tea extracts. Extracts from the four dark tea varieties significantly promoted gastrointestinal transit and colonization of beneficial Bifidobacterium and Lactobacillus, and inhibited the growth of harmful Escherichia coli and Enterococcus in normal mice. In addition, Qianliang tea, Qing brick tea, and Liupao tea extracts significantly accelerated the reversal of the ampicillin sodium-induced pathological damage in the ileum, intestinal bacterial dysbiosis (Bifidobacterium, Lactobacillus, E. coli, and Enterococcus), and low immunity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect