G protein‐coupled receptors: walking hand‐in‐hand, talking hand‐in‐hand?
| Autor: | Anne O. Watts, Saskia Nijmeijer, Rob Leurs, Henry F. Vischer |
|---|---|
| Přispěvatelé: | Medicinal chemistry, AIMMS |
| Rok vydání: | 2011 |
| Předmět: |
Pharmacology
G protein-coupled receptor kinase Allosteric regulation Reviews Receptor Cross-Talk Biology Rhodopsin-like receptors Receptors G-Protein-Coupled Cell biology Crosstalk (biology) Allosteric Regulation SDG 3 - Good Health and Well-being Animals Humans Homomeric Protein Multimerization Signal transduction Signal Transduction G protein-coupled receptor |
| Zdroj: | Vischer, H F, Watts, A O, Nijmeijer, S & Leurs, R 2011, ' G-protein-coupled receptors: walking hand-in-hand, talking hand-in-hand? ', British Journal of Pharmacology, pp. 163-246 . https://doi.org/10.1111/j.1476-5381.2011.01229.x British Journal of Pharmacology, 163-246. Wiley-Blackwell STARTPAGE=163;ENDPAGE=246;ISSN=0007-1188;TITLE=British Journal of Pharmacology |
| ISSN: | 1476-5381 0007-1188 |
| Popis: | Most cells express a panel of different G protein-coupled receptors (GPCRs) allowing them to respond to at least a corresponding variety of extracellular ligands. In order to come to an integrative well-balanced functional response these ligand-receptor pairs can often cross-regulate each other. Although most GPCRs are fully capable to induce intracellular signalling upon agonist binding on their own, many GPCRs, if not all, appear to exist and function in homomeric and/or heteromeric assemblies for at least some time. Such heteromeric organization offers unique allosteric control of receptor pharmacology and function between the protomers and might even unmask 'new' features. However, it is important to realize that some functional consequences that are proposed to originate from heteromeric receptor interactions may also be observed due to intracellular crosstalk between signalling pathways of non-associated GPCRs. © 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society. |
| Databáze: | OpenAIRE |
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