The protective effects of rosmarinic acid on ethanol-induced gastritis in male rats: antioxidant defense enhancement

Autor:	Fatemeh Heidari, Zeinab Hamidizad, Tahereh Komeili-Movahhed, Azam Moslehi
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	medicine.medical_specialty Antioxidant medicine.medical_treatment medicine.disease_cause Superoxide dismutase chemistry.chemical_compound Pharmacy and materia medica Internal medicine Gastric glands medicine alcohol gastritis oxidative stress pge2 rosmarinic acid General Pharmacology Toxicology and Pharmaceutics biology business.industry Stomach Rosmarinic acid Malondialdehyde RS1-441 Endocrinology medicine.anatomical_structure chemistry Oxidative stress Gastritis biology.protein Original Article PGE2 medicine.symptom Alcohol business
Zdroj:	Research in Pharmaceutical Sciences, Vol 16, Iss 3, Pp 305-314 (2021) Research in Pharmaceutical Sciences
ISSN:	1735-9414 1735-5362
Popis:	Background and purpose: Gastritis is one of the most current gastrointestinal disorders worldwide. Alcohol consumption is one of the major factors, which provides gastritis. Rosmarinic acid (RA) is found in many plants and has powerful antioxidant and anti-inflammatory effects. In this study, the protective effect of RA was evaluated on the histopathological indices, antioxidant ability, and prostaglandin E2 (PGE2) secretion in male rats. Experimental approach: Forty-two animals were divided into control, ethanol-induced gastritis, and RA groups, 6 each. The protective groups included RA administration before gastritis induction at 50 mg (R-G50), 100 mg (R-G100), 150 mg (R-G150), and 200 mg (R-G200) doses. Gastritis was induced by gavage of 1 mL pure ethanol in fasted animals. After 1 h of gastritis induction, the rats were sacrificed and stomach tissue was removed. Findings/Results: Histological evaluation revealed that RA significantly attenuated gastric ulcers, leucocyte infiltration, and hyperemia. It also increased mucosal layer thickness and restored gastric glands. Furthermore, RA decreased malondialdehyde level, increased superoxide dismutase, catalase, and glutathione in the stomach tissue, and raised gastric PGE2 level. Conclusion and implications: Our study demonstrated that rosmarinic acid has a notable effect on gastritis protection that could be due to increased antioxidant defense and PGE2 secretion, eventually maintenance of mucosal barrier integrity and gastric glands. Keywords : Alcohol; Gastritis; Oxidative stress; PGE2; Rosmarinic acid.
Databáze:	OpenAIRE
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