Improved handling and embedding schemes for cultured murine neuroretinal explants

Autor:	Susan Haller, Rebecca M. Marton, Kevin A. Marroquin, Eliah R. Shamir
Rok vydání:	2022
Předmět:	Medical Laboratory Technology Histology Anatomy
Zdroj:	Journal of Histotechnology. 45:182-194
ISSN:	2046-0236 0147-8885
Popis:	Traumatic, inherited, and age-related degenerative diseases of the retina, such as retinal detachment, retinitis pigmentosa, and age-related macular degeneration, are characterized by the irreversible loss of retinal neurons. While current treatments aim to prevent neuronal degeneration, there are no available treatments to restore neurons after loss. Cultured murine neuroretinal tissue explants model retinal injury and offer a high throughput approach to identify experimental interventions capable of regenerating neurons. Formalin-fixed paraffin-embedded (FFPE) preparations of murine neuroretinal explants can be used to identify cells throughout the retinal layers to provide information on proliferation and activity following exposure to therapeutics. However, retinal explants are friable, particularly after
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0faa99e293938e14e5c019944fe0da6 https://doi.org/10.1080/01478885.2022.2119639 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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