Intermittent pair-housing, pair relationship qualities, and HPA activity in adult female rhesus macaques
| Autor: | Allison Barnard, Lauren C. Cassidy, Brenda McCowan, Darcy L. Hannibal, Stuart Semple, Sasha L. Winkler, Katie Chun, Jessica J. Vandeleest |
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| Rok vydání: | 2017 |
| Předmět: |
0106 biological sciences
medicine.medical_specialty Hypothalamo-Hypophyseal System Hydrocortisone Pituitary-Adrenal System Audiology Animal Welfare 010603 evolutionary biology 01 natural sciences Article Fight-or-flight response Hpa activity Condition part biology.animal Animals Laboratory Urinary free cortisol medicine Animals 0501 psychology and cognitive sciences Model set Primate 050102 behavioral science & comparative psychology Social Behavior Ecology Evolution Behavior and Systematics Adult female biology 05 social sciences biology.organism_classification Housing Animal Macaca mulatta Rhesus macaque Animal Science and Zoology Female Psychology Stress Psychological |
| Zdroj: | Am J Primatol |
| ISSN: | 1098-2345 |
| Popis: | Laboratory rhesus macaques are often housed in pairs and may be temporarily or permanently separated for research, health, or management reasons. While both long-term social separations and introductions can stimulate a stress response that impacts inflammation and immune function, the effects of short-term overnight separations and whether qualities of the pair relationship mediate these effects are unknown. In this study, we investigated the effects of overnight separations on the urinary cortisol concentration of 20 differentially paired adult female rhesus macaques (Macaca mulatta) at the California National Primate Research Center. These females were initially kept in either continuous (no overnight separation) or intermittent (with overnight separation) pair-housing and then switched to the alternate pair-housing condition part way through the study. Each study subject was observed for 5 weeks, during which we collected measures of affiliative, aggressive, anxious, abnormal, and activity-state behaviors in both pair-housing conditions. Additionally, up to three urine samples were collected from each subject per week and assayed for urinary free cortisol and creatinine. Lastly, the behavioral observer scored each pair on four relationship quality attributes ("Anxious," "Tense," "Well-meshed," and "Friendly") using a seven-point scale. Data were analyzed using a generalized linear model with gamma distribution and an information theoretic approach to determine the best model set. An interaction between the intermittent pairing condition and tense pair adjective rating was in the top three models of the best model set. Dominance and rates of affiliation were also important for explaining urinary cortisol variation. Our results suggest that to prevent significant changes in HPA-axis activation in rhesus macaque females, which could have unintended effects on research outcomes, pairs with "Tense" relationships and overnight separations preventing tactile contact should be avoided. |
| Databáze: | OpenAIRE |
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