Pathogenicity of Genetically Similar, H5N1 Highly Pathogenic Avian Influenza Virus Strains in Chicken and the Differences in Sensitivity among Different Chicken Breeds

Autor: Tomoko Kobayashi, Yasuaki Hiromoto, Tuangthong Patchimasiri, Takashi Shiina, Aya Matsuu, Kridsada Chaichoune, Sujira Parchariyanon, Parntep Ratanakorn, Shingo Suzuki, Haruka Abe, Takehiko Saito
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
RNA viruses
Thai People
Physiology
lcsh:Medicine
Artificial Gene Amplification and Extension
Pathogenesis
Breeding
medicine.disease_cause
Virus Replication
Polymerase Chain Reaction
Poultry
law.invention
law
Zoonoses
Immune Physiology
Ethnicities
Gamefowl
lcsh:Science
Polymerase chain reaction
Pathology and laboratory medicine
Innate Immune System
Multidisciplinary
Virulence
Reverse Transcriptase Polymerase Chain Reaction
Agriculture
H5N1
Medical microbiology
Virus Shedding
Infectious Diseases
Influenza A virus
Vertebrates
Viruses
Cytokines
Pathogens
Research Article
animal structures
Livestock
030106 microbiology
Immunology
Molecular Sequence Data
Biology
Research and Analysis Methods
Microbiology
Virus
Host Specificity
Birds
Avian Proteins
03 medical and health sciences
Species Specificity
Virology
medicine
Animals
Influenza viruses
Humans
Viral shedding
Molecular Biology Techniques
Gene
Molecular Biology
Medicine and health sciences
Influenza A Virus
H5N1 Subtype
Host (biology)
lcsh:R
Organisms
Viral pathogens
Biology and Life Sciences
Sequence Analysis
DNA
Molecular Development
Influenza A virus subtype H5N1
Viral Replication
Microbial pathogens
030104 developmental biology
Viral replication
Fowl
Immune System
Influenza in Birds
Amniotes
People and Places
lcsh:Q
Population Groupings
Chickens
Orthomyxoviruses
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 11, Iss 4, p e0153649 (2016)
PLOS ONE
ISSN: 1932-6203
Popis: Differences in the pathogenicity of genetically closely related H5N1 highly pathogenic avian influenza viruses (HPAIVs) were evaluated in White Leghorn chickens. These viruses varied in the clinical symptoms they induced, including lethality, virus shedding, and replication in host tissues. A comparison of the host responses in the lung, brain, and spleen suggested that the differences in viral replication efficiency were related to the host cytokine response at the early phase of infection, especially variations in the proinflammatory cytokine IL-6. Based on these findings, we inoculated the virus that showed the mildest pathogenicity among the five tested, A/pigeon/Thailand/VSMU-7-NPT/2004, into four breeds of Thai indigenous chicken, Phadu-Hung-Dang (PHD), Chee, Dang, and Luang-Hung-Khao (LHK), to explore effects of genetic background on host response. Among these breeds, Chee, Dang, and LHK showed significantly longer survival times than White Leghorns. Virus shedding from dead Thai indigenous chickens was significantly lower than that from White Leghorns. Although polymorphisms were observed in the Mx and MHC class I genes, there was no significant association between the polymorphisms in these loci and resistance to HPAIV.
Databáze: OpenAIRE
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