Prolonging GnRH-agonist to achieve ovarian suppression does not compromise the results of a long protocol
| Autor: | Delphine Ferrier, M. Jean, Thomas Fréour, Paul Barrière, Lionel Dessolle, Agnès Colombel |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Time Factors Pregnancy Rate medicine.medical_treatment Drug Resistance Urology Fertilization in Vitro Controlled ovarian hyperstimulation Hormone antagonist Gonadotropin-Releasing Hormone Hormone Antagonists Pregnancy medicine Humans Ovulation Inhibition Embryo Implantation Prospective Studies Prospective cohort study Ultrasonography Gynecology In vitro fertilisation Estradiol business.industry Ovary Obstetrics and Gynecology Embryo Transfer medicine.disease Embryo transfer Pregnancy rate ROC Curve Reproductive Medicine Infertility Female Live birth business Live Birth |
| Zdroj: | European Journal of Obstetrics & Gynecology and Reproductive Biology. 159:111-114 |
| ISSN: | 0301-2115 |
| DOI: | 10.1016/j.ejogrb.2011.06.030 |
| Popis: | Objectives In the long gonadotropin-releasing hormone agonist (GnRHa) protocols, stimulation is delayed until complete pituitary–ovarian suppression has been achieved, which usually takes a minimum of 10 days. In women who do not achieve timely suppression we set out to evaluate if prolonging GnRHa affects the results of the IVF process. Study design We analyzed cycle and pregnancy outcome in 506 consecutive women undergoing IVF-ET after a standardized long GnRHa protocol, according to the time required to achieve ovarian suppression (i.e. estradiol 6 mm at ultrasound). Results Suppression was obtained after 14 GnRHa days in 383 (75.70%) women (Group 1) and 123 (24.30%) women (Group 2) required a mean ± SD (range) of 10 ± 4 (7–28) additional days to achieve complete suppression. Both groups were comparable for baseline clinical and biological characteristics. The rate of cancelled cycles due to poor ovarian response, the number of the oocytes retrieved, fertilization rates, the number and quality of the embryos cultured and transferred were similar in both groups, as well as the pregnancy, implantation and live birth rates. In Group 2, receiver–operator characteristics analysis showed that the probability of pregnancy was not related to the duration of GnRHa treatment. Conclusions In a standardized long GnRHa protocol, prolonging desensitization to achieve complete ovarian suppression does not affect the outcome. |
| Databáze: | OpenAIRE |
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