Diagnosis of mast cell activation syndrome: a global 'consensus-2'
| Autor: | Jill R. Cuni, Ilene S. Ruhoy, Emma J. Reinhold, Stephanie J. Kratzer, Peter C. Rowe, Ariana D. Buchanan, Mark Westaway, Laurie Radovsky, William Patrick Davey, Andrew J. Maxwell, William A. Robinson, Martina Wengenroth, Kimberly J. Hindman, Jill R. Schofield, David L. Kaufman, Mindy S. Marantz, David A. Schlosser, Dahra D. Perkins, Dwight L. McKee, Jill B Brook, E. Scott Rosenbloom, Leonard B. Weinstock, Laura A. Pace, Alena G. Guggenheim, Sonia A. Rapaport, Mark Renneker, Gerhard J. Molderings, Linda S. Bluestein, Martin S. Dubravec, Tania T. Dempsey, Joseph H. Brewer, Shanda R. Dorff, Aaron M. Roland, Mary B. Ackerley, Shijun Cindy Xi, Janet E. Settle, Bruce Hoffman, Lawrence B. Afrin, Kelly K. McCann, David S. Saperstein, Laurie Menk Otto, Theodore M. Lee, Mary S. Raleigh |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Consensus Clinical Biochemistry Population Medicine (miscellaneous) Illness duration Mast cell activation syndrome Disease 03 medical and health sciences 0302 clinical medicine Medicine Humans Mast Cells Overdiagnosis education Mast Cell Activation Disease education.field_of_study business.industry Health Policy Biochemistry (medical) Public Health Environmental and Occupational Health 030104 developmental biology 030228 respiratory system Immunology medicine.symptom business Mastocytosis |
| Zdroj: | Diagnosis (Berlin, Germany)References. 8(2) |
| ISSN: | 2194-802X |
| Popis: | The concept that disease rooted principally in chronic aberrant constitutive and reactive activation of mast cells (MCs), without the gross MC neoplasia in mastocytosis, first emerged in the 1980s, but only in the last decade has recognition of “mast cell activation syndrome” (MCAS) grown significantly. Two principal proposals for diagnostic criteria have emerged. One, originally published in 2012, is labeled by its authors as a “consensus” (re-termed here as “consensus-1”). Another sizable contingent of investigators and practitioners favor a different approach (originally published in 2011, newly termed here as “consensus-2”), resembling “consensus-1” in some respects but differing in others, leading to substantial differences between these proposals in the numbers of patients qualifying for diagnosis (and thus treatment). Overdiagnosis by “consensus-2” criteria has potential to be problematic, but underdiagnosis by “consensus-1” criteria seems the far larger problem given (1) increasing appreciation that MCAS is prevalent (up to 17% of the general population), and (2) most MCAS patients, regardless of illness duration prior to diagnosis, can eventually identify treatment yielding sustained improvement. We analyze these proposals (and others) and suggest that, until careful research provides more definitive answers, diagnosis by either proposal is valid, reasonable, and helpful. |
| Databáze: | OpenAIRE |
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