Discovery of Mating in the Major African Livestock Pathogen Trypanosoma congolense
| Autor: | Robert M. Christley, Andreas Schoenefeld, Annette MacLeod, Andy Tait, Alana Black, Gina Pinchbeck, Christiane Hertz-Fowler, Liam J. Morrison, Alison Tweedie, C. Michael R. Turner |
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| Rok vydání: | 2009 |
| Předmět: |
Infectious Diseases/Epidemiology and Control of Infectious Diseases
Linkage disequilibrium Genotype Trypanosoma congolense 030231 tropical medicine lcsh:Medicine Population genetics Biology Sexual Behavior Animal 03 medical and health sciences 0302 clinical medicine Genetics and Genomics/Population Genetics Animals Parasite hosting Microbiology/Parasitology Mating lcsh:Science Phylogeny 030304 developmental biology Medicine(all) Genetics 0303 health sciences Genetic diversity Polymorphism Genetic Microbiology/Microbial Evolution and Genomics Multidisciplinary Agricultural and Biological Sciences(all) Biochemistry Genetics and Molecular Biology(all) business.industry lcsh:R Infectious Diseases/Protozoal Infections biology.organism_classification Genetics Population Evolutionary biology Trypanosoma lcsh:Q Livestock business Microsatellite Repeats Research Article |
| Zdroj: | Morrison, L J, Tweedie, A, Black, A, Pinchbeck, G L, Christley, R M, Schoenefeld, A, Hertz-Fowler, C, MacLeod, A, Turner, C M R & Tait, A 2009, ' Discovery of mating in the major African livestock pathogen Trypanosoma congolense ', PLoS ONE, vol. 4, no. 5, e5564 . https://doi.org/10.1371/journal.pone.0005564 PLoS ONE PLoS ONE, Vol 4, Iss 5, p e5564 (2009) |
| ISSN: | 1932-6203 |
| Popis: | The protozoan parasite, Trypanosoma congolense, is one of the most economically important pathogens of livestock in Africa and, through its impact on cattle health and productivity, has a significant effect on human health and well being. Despite the importance of this parasite our knowledge of some of the fundamental biological processes is limited. For example, it is unknown whether mating takes place. In this paper we have taken a population genetics based approach to address this question. The availability of genome sequence of the parasite allowed us to identify polymorphic microsatellite markers, which were used to genotype T. congolense isolates from livestock in a discrete geographical area of The Gambia. The data showed a high level of diversity with a large number of distinct genotypes, but a deficit in heterozygotes. Further analysis identified cryptic genetic subdivision into four sub-populations. In one of these, parasite genotypic diversity could only be explained by the occurrence of frequent mating in T. congolense. These data are completely inconsistent with previous suggestions that the parasite expands asexually in the absence of mating. The discovery of mating in this species of trypanosome has significant consequences for the spread of critical traits, such as drug resistance, as well as for fundamental aspects of the biology and epidemiology of this neglected but economically important pathogen. |
| Databáze: | OpenAIRE |
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