Mitochondrial Polymorphisms Are Associated Both with Increased and Decreased Longevity
| Autor: | Donata Luiselli, Reynaldo Pereira, Ramon Villegas-Palma, Henrieta Raventos, Mauricio Melendez-Obando, Lorena Madrigal, Davide Pettener, Ramiro Barrantes, Loredana Castrì |
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| Přispěvatelé: | Castri L, Melendez-Obando M, Villegas-Palma R, Barrantes R, Raventos H, Pereira R, Luiselli D, Pettener D, Madrigal L. |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Costa Rica
Genetic Markers Mitochondrial DNA media_common.quotation_subject Population Longevity Biology 5178A DNA Mitochondrial Haplogroup Statistics Nonparametric 03 medical and health sciences MTDNA Genetics Humans education Genetics (clinical) 030304 developmental biology media_common 0303 health sciences education.field_of_study Original Paper Analysis of Variance Polymorphism Genetic mtDNA 030305 genetics & heredity Haplotype Genética 3. Good health Haplotypes Genetic marker Mutation (genetic algorithm) Mutation 150T Analysis of variance MATERNAL GENEALOGY |
| Zdroj: | Kérwá Universidad de Costa Rica instacron:UCR |
| Popis: | artículo (arbitrado) -- Universidad de Costa Rica, Centro de investigaciones en Biología Celular y Molecular, 2008. Este documento es privado debido a limitaciones de derechos de autor. Previous work compared frequency of longevity-associated polymorphisms (LAPS) in long-lived individuals and in controls from the general population (primarily in Europe and Japan), suggesting the polymorphisms are responsible for unusual longevity. However, individuals from the general population are not the control group for long-lived subjects because both were born in different periods. We report results of a project which collected mtDNA from living subjects in Costa Rica, and traced back their maternal genealogy. Since mtDNA does not recombine and its probability of mutation is low, we can assume that the maternal ancestors had the same mtDNA of their descendants. We compared the longevity of individuals with LAPS with the longevity of controls born in the same time period. We did not confirm previous associations for several markers, but found that the 5178A mutation in haplogroup D is associated with decreased longevity, whereas the 150T mutation is associated with increased longevity. These associations however, are not significant for all time periods under study. While our data confirm that mtDNA make up affects longevity, they also indicate that the time period in which a person was born had a much greater impact on longevity than presence or absence of a marker. Supported by a grant from the National Institutes of Aging (1-R03-AG022616-01) UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM) |
| Databáze: | OpenAIRE |
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