A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats
| Autor: | Jorge D. Brioni, Kaitlin E. Browman, Victoria A. Komater, Robert B. Moreland, Angela L. Molesky, Jia Bao Pan, Gerard B. Fox, Peter Curzon, Michael W. Decker |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Agonist Pyridines medicine.drug_class Clinical Biochemistry Motor Activity Pharmacology Toxicology Biochemistry Dopamine agonist Rats Sprague-Dawley Behavioral Neuroscience Cognition Memory Dopamine Rats Inbred SHR Dopamine receptor D2 Acetamides medicine Animals Rats Wistar Spontaneous hypertensive rat Receptor Biological Psychiatry Receptors Dopamine D4 Rats A-412997 Dopamine receptor Dopamine Agonists Psychology Neuroscience medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 82:148-155 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/j.pbb.2005.08.002 |
| Popis: | The recent development of a highly selective dopamine D4 receptor agonist, A-412997 (2-(3',4',5',6'-tetrahydro-2'H-[2,4'] bipyridinyl-1'-yl)-N-m-tolyl-acetamide), has provided a pharmacological tool with which to conduct systematic investigations into the putative role for dopamine D4 receptors in the central nervous system. These present studies evaluated the potential cognitive enhancing properties of A-412997 in rat models of ADHD (5-trial repeated acquisition inhibitory avoidance in Spontaneous Hypertensive Rat pups) and short-term memory (Social Recognition), in comparison with the less selective dopamine D4 receptor agonists PD168077 and CP226269. A-412997 showed significant dose-dependent efficacy in both models. PD168077 repeatedly improved acquisition in the 5-trial inhibitory avoidance model but failed to reach significance at any dose tested, although significantly improved social recognition was observed (albeit less potent than A-412997). CP226269 showed a significant enhancement in the 5-trial inhibitory avoidance model. These results support a role for the dopamine D4 receptor subtype in cognition. |
| Databáze: | OpenAIRE |
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