PITUITARY GONADOTROPHIN INHIBITORY ACTION OF NEUTRAL STEROIDS
| Autor: | Dorfman Ri, Kincl Fa |
|---|---|
| Rok vydání: | 1964 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Injections Subcutaneous Anal Canal Parabiosis Ovary Inhibitory postsynaptic potential Body weight Chorionic Gonadotropin chemistry.chemical_compound Endocrinology Internal medicine Testis medicine Humans Testosterone Castration Injections subcutaneous Pharmacology Chemistry Body Weight Prostate Seminal Vesicles General Medicine 17-Ketosteroids Rats medicine.anatomical_structure Pituitary gonadotrophin Gonadotropins Pituitary Androgens Biological Assay Female Orchiectomy |
| Zdroj: | Acta endocrinologica. 46 |
| ISSN: | 0001-5598 |
| Popis: | Thirty-one neutral steroids have been studied for their anti-gonadotrophic activity in a parabiosis test using castrated male and intact female rats. The previous observation that the anti-pituitary activity of certain steroids need not parallel the androgen activity and is frequently correlated with the levator ani activity has been confirmed. By the subcutaneous injection route, compared to testosterone 100, the following relative anti-pituitary activities were determined: 6α-chlorotestosterone acetate (375); 6α-fluorotestosterone (350); 2-nitrilo-17α-methyl-5α-androst-2-en-17β-ol (350); 2-formyl-5α-androst-2-en-17β-ol (250); 2-hydroxymethyl-5α-androst-2-en-17β-ol (220) and 6α,17α-dimethyl-17β-hydroxy-5α-androstan-3-one (200). Particularly favourable separations in gonadotrophin inhibition and androgenicity were found for 2-formyl-5α-androst-2-en-17β-ol, ratio 25 (testosterone ratio = 1) for 2-hydroxymethyl-5α-androst-2-en-17β-ol, ratio 11 and for 2-methyl-5α-androst-2-en-17β-ol, ratio 6. |
| Databáze: | OpenAIRE |
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