Identification of potential prognostic factors for absence of residual disease in the second resection of T1 bladder cancer
| Autor: | Łukasz Curyło, Piotr Chlosta, Anna Czech, Katarzyna Gronostaj, Przemyslaw Dudek, Jakub Fronczek, Tomasz Wiatr, Jerzy Gąsowski, Jakub Frydrych, Mikolaj Przydacz |
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| Rok vydání: | 2019 |
| Předmět: |
second TURBT
Detrusor muscle Original Paper medicine.medical_specialty Bladder cancer business.industry Mitomycin C 030232 urology & nephrology Urology Retrospective cohort study General Medicine Odds ratio Disease medicine.disease Logistic regression second look 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure non-muscle invasive bladder cancer 030220 oncology & carcinogenesis transurethral resection Medicine business Prospective cohort study |
| Zdroj: | Central European Journal of Urology |
| ISSN: | 2080-4873 |
| DOI: | 10.5173/ceju.2019.1908 |
| Popis: | Introduction The aim of this single centre retrospective study was to analyse the results of second resection (repeat transurethral resection of bladder tumour - reTURBT) after a macroscopically complete resection of T1 urothelial bladder tumour and to identify prognostic factors for absence of residual disease (T0) in the second resection of T1 bladder cancer. Material and methods Patients with T1 bladder cancer diagnosed in a macroscopically complete initial resection who underwent second resection within 12 weeks were included into the retrospective analysis. Based on the presence or absence of residual disease, patients were grouped for further analysis. Univariate and multivariable logistic regressions were performed to identify potential prognostic factors. Results Among the 139 patients who met the inclusion criteria, 96 (69.1%) had no residual disease (T0) and 43 (30.9%) had residual disease in the second resection (including muscle invasive bladder cancer in 2.2%). Adjusted odds ratios (OR) of T0 status obtained from the final model were as follows: detrusor muscle presence in the first resection (OR 3.05; 95% CI 1.12-8.35, p = 0.03), immediate post-operative intravesical mitomycin C administration after the first TURBT (OR 2.52, 95% CI 1.12-5.68; p = 0.03) and primary bladder cancer setting (OR 2.45, 95% CI 1.10-5.47; p = 0.03). Conclusions Our results add evidence regarding the importance of detrusor muscle presence in the first TURBT. Identification of predictors of T0 status at second resection could help design prospective studies assessing the possibility to avoid re-resection in selected patients with T1 bladder cancer without compromising oncological outcomes. |
| Databáze: | OpenAIRE |
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