Reverse translated and gold standard continuous performance tests predict global cognitive performance in schizophrenia
| Autor: | Melissa Tarasenko, Jared W. Young, Sonia Rackelmann, Michael L. Thomas, Andrew W. Bismark, Alexandra L. Shiluk, Gregory A. Light |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male endocrine system endocrine system diseases media_common.quotation_subject Clinical Sciences Neuropsychological Tests Basic Behavioral and Social Science Article lcsh:RC321-571 Young Adult 03 medical and health sciences Cellular and Molecular Neuroscience Cognition 0302 clinical medicine Clinical Research Continuous performance task Perception Behavioral and Social Science medicine Humans Psychology Attention heterocyclic compounds Cognitive skill Effects of sleep deprivation on cognitive performance lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry neoplasms Biological Psychiatry media_common medicine.diagnostic_test Working memory Neurosciences Regression analysis Middle Aged digestive system diseases Brain Disorders 030227 psychiatry Psychiatry and Mental health Mental Health Schizophrenia Public Health and Health Services Schizophrenic Psychology Female 030217 neurology & neurosurgery Vigilance (psychology) Cognitive psychology |
| Zdroj: | Translational Psychiatry, Vol 8, Iss 1, Pp 1-8 (2018) Translational psychiatry, vol 8, iss 1 Translational Psychiatry Bismark, AW; Thomas, ML; Tarasenko, M; Shiluk, AL; Rackelmann, SY; Young, JW; et al.(2018). Reverse translated and gold standard continuous performance tests predict global cognitive performance in schizophrenia. TRANSLATIONAL PSYCHIATRY, 8. doi: 10.1038/s41398-018-0127-5. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/2ng5t7nq |
| ISSN: | 2158-3188 |
| Popis: | Attentional dysfunction contributes to functional impairments in schizophrenia (SZ). Sustained attention is typically assessed via continuous performance tasks (CPTs), though many CPTs have limited cross-species translational validity and place demands on additional cognitive domains. A reverse-translated 5-Choice Continuous Performance Task (5C-CPT) for human testing—originally developed for use in rodents—was designed to minimize demands on perceptual, visual learning, processing speed, or working memory functions. To-date, no studies have validated the 5C-CPT against gold standard attentional measures nor evaluated how 5C-CPT scores relate to cognition in SZ. Here we examined the relationship between the 5C-CPT and the CPT-Identical Pairs (CPT-IP), an established and psychometrically robust measure of vigilance from the MATRICS Consensus Cognitive Battery (MCCB) in a sample of SZ patients (n = 35). Relationships to global and individual subdomains of cognition were also assessed. 5C-CPT and CPT-IP measures of performance (d-prime) were strongly correlated (r = 0.60). In a regression model, the 5C-CPT and CPT-IP collectively accounted for 54% of the total variance in MCCB total scores, and 27.6% of overall cognitive variance was shared between the 5C-CPT and CPT-IP. These results indicate that the reverse translated 5C-CPT and the gold standard CPT-IP index a common attentional construct that also significantly overlaps with variance in general cognitive performance. The use of simple, cross-species validated behavioral indices of attentional/cognitive functioning such as the 5C-CPT could accelerate the development of novel generalized pro-cognitive therapeutics for SZ and related neuropsychiatric disorders. |
| Databáze: | OpenAIRE |
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