GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN THE TREATMENT OF NEONATES WITH NEUTROPENIA AND SEPSIS
| Autor: | Sheldon B. Korones, Rhonda Dancy, Winfred C. Wang, Judith A. Wilimas, F. Ann Hayes, Lakshmi Venkateswaran, Jane Hayden |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Neutropenia medicine.medical_treatment Gastroenterology Sepsis Internal medicine White blood cell medicine Humans Chemotherapy Leukopenia business.industry Septic shock Infant Newborn Granulocyte-Macrophage Colony-Stimulating Factor Hematology medicine.disease medicine.anatomical_structure Oncology Concomitant Injections Intravenous Pediatrics Perinatology and Child Health Immunology Absolute neutrophil count medicine.symptom business |
| Zdroj: | Pediatric Hematology and Oncology. 17:469-473 |
| ISSN: | 1521-0669 0888-0018 |
| DOI: | 10.1080/08880010050120827 |
| Popis: | To evaluate the efficacy of granulocyte-macrophage colony-stimulating factor (GM-CSF) in improving neutrophil counts and survival of neutropenic septic neonates, the authors studied 8 neonates with gestational or postconceptional age at least 30 weeks; weight at least 1000 g; serious infection with concomitant neutropenia (absolute neutrophil count [ANC]3.0 x 10(9)/L) or leukopenia (white blood cell count5.0 x 10(9)/L) and anticipated survival at least 48 h. Patients received 5 micrograms/kg of GM-CSF intravenously for 5 consecutive days or until the ANC reached 20 x 10(9)/L. Clinical parameters and complete blood counts were monitored. Prestudy ANCs ranged from 0.05 to 2.7 x 10(9)/L. Four patients had positive blood cultures, 4 had necrotizing enterocolitis, and 1 was in septic shock. All patients had elevated C-reactive protein. All patients had resolution of neutropenia and survived the septic episodes. The use of GM-CSF in these patients merits further exploration. |
| Databáze: | OpenAIRE |
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