Changes in bone mineral density after orchidectomy and hormone replacement therapy in individuals with androgen insensitivity syndrome
| Autor: | Issei Kagami, Sumitaka Miyamoto, Hideki Mizunuma, Masayuki Soda, Hiroya Okano, Yoshito Ibuki, Minoru Ohsawa |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Time Factors medicine.drug_class Medroxyprogesterone Acetate Biology Complete androgen insensitivity syndrome Bone Density Internal medicine medicine Hormone replacement therapy (male-to-female) Medroxyprogesterone acetate Humans Testosterone Testicular feminization Bone mineral Estradiol musculoskeletal neural and ocular physiology Rehabilitation Estrogen Replacement Therapy Obstetrics and Gynecology Estrogens Androgen-Insensitivity Syndrome musculoskeletal system Androgen medicine.disease Endocrinology Reproductive Medicine Androgen insensitivity syndrome Orchiectomy medicine.drug |
| Zdroj: | Human reproduction (Oxford, England). 13(1O) |
| ISSN: | 0268-1161 |
| Popis: | Changes in bone mineral density (BMD) after orchidectomy and after hormone replacement therapy were reported in two patients with complete androgen insensitivity syndrome (AIS). Diagnosis of AIS was made by clinical features and confirmed by the presence of 46,XY karyotype and the presence of testis component in the removed gonads. BMD at the lumbar spine and at three sites of the femur was measured by dual energy X-ray absorptiometry (DXA). The Z scores of the lumbar spine BMD before orchidectomy were -0.8 and -3.1, confirming that patients with AIS have low BMD and that androgen plays an important role in bone mineralization in 46,XY individuals. Castration reduced BMD, but treatment with daily doses of 1.25 mg of conjugated oestrogen and 10 mg of medroxyprogesterone acetate increased BMD. These results indicate that both oestrogen and androgen play an important role in balancing BMD in men. |
| Databáze: | OpenAIRE |
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